If the ecosystems that we are part of and rely on are to flourish, we must urgently transform how we live, and how we imagine living. Design education has a critical role to play in this transformation, as design is a materially engaged, world-building activity. Design is complicit in the problems we are facing, and informs and shapes how people live. In this article, I seed ideas about design research education for global challenges. I speak to the merits of post-disciplinary and hybrid strategies, and look to science for clues about how to respond to twenty-first-century challenges through design. I posit sustainability brokering as a new pathway for design, and anticipating alternative futures as a critical step in developing transformative innovation. I then propose participatory research through design as a foundational methodology; describe four pillars of practice to scaffold sophisticated research at undergraduate and master’s level; and lay out a work plan for building research capacity in a doctoral school. Through this process, I articulate core skills that design researchers will likely require if they are to contribute to global challenges constructively. My aim is to seed fruitful regenerative discussion with these propositions.