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Computerized cognitive training in Parkinson's disease: A systematic review and meta-analysis
Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi. Academic Unit for Psychiatry of Old Age, University of Melbourne, Parkville, Australia.ORCID-id: 0000-0003-3256-9018
Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.ORCID-id: 0000-0002-2348-1164
Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Camperdown, Australia; Central Clinical School, Faculty of Medicine and Health, Charles Perkins Centre, University of Sydney, Camperdown, Australia.
Department of Social and Psychological Studies, Karlstad University, Karlstad, Sweden.
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2022 (Engelska)Ingår i: Ageing Research Reviews, ISSN 1568-1637, E-ISSN 1872-9649, Vol. 80, artikel-id 101671Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

Cognitive impairment is a central non-motor symptom of Parkinson's disease (PD), and there are no established treatments. Computerized cognitive training (CCT) is a safe and efficacious strategy but its efficacy in PD is unclear. We aimed to investigate the efficacy of CCT on cognitive, psychosocial and daily function, and assess potential effect moderators in people with PD without dementia. Randomized controlled trials of CCT were included in multivariate meta-analyses and meta-regressions. Seventeen studies (16 trials) encompassing 679 participants were included. The pooled effect of CCT relative to control was small and statistically significant for overall cognitive function (g=0.16; 95% CI 0.02–0.29). There was robust evidence for benefit on clinical measures of global cognition across 10 trials (g=0.33; 95% CI 0.19–0.48), especially in PD with mild cognitive impairment (PD-MCI), as well as on individual cognitive domains. Greater CCT dose and PD-MCI population were associated with larger effect sizes, but no statistically significant differences were found between subgroups. There was no significant difference in the efficacy of home-based compared to supervised training. Our findings suggest that CCT is associated with cognitive benefits in PD, including when delivered remotely. Larger, well-powered trials are warranted to examine what specific CCT regimens are most likely to promote cognitive and everyday functioning in the long-term.

Ort, förlag, år, upplaga, sidor
Elsevier, 2022. Vol. 80, artikel-id 101671
Nyckelord [en]
Cognitive training, Meta-analysis, Parkinson's disease, Systematic review
Nationell ämneskategori
Geriatrik
Identifikatorer
URN: urn:nbn:se:umu:diva-198218DOI: 10.1016/j.arr.2022.101671ISI: 000841188700002PubMedID: 35714854Scopus ID: 2-s2.0-85133739803OAI: oai:DiVA.org:umu-198218DiVA, id: diva2:1684217
Forskningsfinansiär
Forte, Forskningsrådet för hälsa, arbetsliv och välfärd, 2014–01654Vetenskapsrådet, 2017–02371Tillgänglig från: 2022-07-22 Skapad: 2022-07-22 Senast uppdaterad: 2023-12-20Bibliografiskt granskad

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M. Gavelin, HannaDomellöf, Magdalena E.

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