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Tremor evaluation using smartphone accelerometry in standardized settings
Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Sciences, Lund University, Lund, Sweden; Department of Internal Medicine, Hässleholm Hospital, Region, Hässleholm, Skåne, Sweden; Skåneuro Neurology Clinic, Lund, Sweden.
Integrative Neurophysiology and Neurotechnology, Department of Experimental Medical Sciences, Lund University, Lund, Sweden.
Skåneuro Neurology Clinic, Lund, Sweden; Department of Clinical Sciences of Malmö and Lund, Lund University, Lund, Sweden.
Centre for Mathematical Sciences, Mathematical, Statistics, Lund University, Lund, Sweden.
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2022 (English)In: Frontiers in Neuroscience, ISSN 1662-4548, E-ISSN 1662-453X, Vol. 16, article id 861668Article in journal (Refereed) Published
Abstract [en]

Tremor can be highly incapacitating in everyday life and typically fluctuates depending on motor state, medication status as well as external factors. For tremor patients being treated with deep-brain stimulation (DBS), adapting the intensity and pattern of stimulation according the current needs therefore has the potential to generate better symptomatic relief. We here describe a procedure for how patients independently could perform self-tests in their home to generate sensor data for on-line adjustments of DBS parameters. Importantly, the inertia sensor technology needed exists in any standard smartphone, making the procedure widely accessible. Applying this procedure, we have characterized detailed features of tremor patterns displayed by both Parkinson's disease and essential tremor patients and directly compared measured data against both clinical ratings (Fahn-Tolosa-Marin) and finger-attached inertia sensors. Our results suggest that smartphone accelerometry, when used in a standardized testing procedure, can provide tremor descriptors that are sufficiently detailed and reliable to be used for closed-loop control of DBS.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2022. Vol. 16, article id 861668
Keywords [en]
closed-loop, essential tremor, inertia sensors, neuromodulation, Parkinson's disease
National Category
Neurology
Identifiers
URN: urn:nbn:se:umu:diva-199020DOI: 10.3389/fnins.2022.861668ISI: 000844625300001PubMedID: 35979340Scopus ID: 2-s2.0-85136203856OAI: oai:DiVA.org:umu-199020DiVA, id: diva2:1692499
Funder
VinnovaSwedish Research Council, 2021-01769Royal Physiographic Society in LundParkinsonfondenPromobilia foundationLund UniversityAvailable from: 2022-09-02 Created: 2022-09-02 Last updated: 2022-09-02Bibliographically approved

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Petersson, Per

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