Tremor evaluation using smartphone accelerometry in standardized settingsVisa övriga samt affilieringar
2022 (Engelska)Ingår i: Frontiers in Neuroscience, ISSN 1662-4548, E-ISSN 1662-453X, Vol. 16, artikel-id 861668
Artikel i tidskrift (Refereegranskat) Published
Abstract [en]
Tremor can be highly incapacitating in everyday life and typically fluctuates depending on motor state, medication status as well as external factors. For tremor patients being treated with deep-brain stimulation (DBS), adapting the intensity and pattern of stimulation according the current needs therefore has the potential to generate better symptomatic relief. We here describe a procedure for how patients independently could perform self-tests in their home to generate sensor data for on-line adjustments of DBS parameters. Importantly, the inertia sensor technology needed exists in any standard smartphone, making the procedure widely accessible. Applying this procedure, we have characterized detailed features of tremor patterns displayed by both Parkinson's disease and essential tremor patients and directly compared measured data against both clinical ratings (Fahn-Tolosa-Marin) and finger-attached inertia sensors. Our results suggest that smartphone accelerometry, when used in a standardized testing procedure, can provide tremor descriptors that are sufficiently detailed and reliable to be used for closed-loop control of DBS.
Ort, förlag, år, upplaga, sidor
Frontiers Media S.A., 2022. Vol. 16, artikel-id 861668
Nyckelord [en]
closed-loop, essential tremor, inertia sensors, neuromodulation, Parkinson's disease
Nationell ämneskategori
Neurologi
Identifikatorer
URN: urn:nbn:se:umu:diva-199020DOI: 10.3389/fnins.2022.861668ISI: 000844625300001PubMedID: 35979340Scopus ID: 2-s2.0-85136203856OAI: oai:DiVA.org:umu-199020DiVA, id: diva2:1692499
Forskningsfinansiär
VinnovaVetenskapsrådet, 2021-01769Kungliga Fysiografiska Sällskapet i LundParkinsonfondenStiftelsen PromobiliaLunds universitet2022-09-022022-09-022022-09-02Bibliografiskt granskad