Detection and localization of early- and late-stage cancers using platelet RNA

In ’t Veld, Sjors G.J.G.; Arkani, Mohammad; Post, Edward; Antunes-Ferreira, Mafalda; D'Ambrosi, Silvia; Vessies, Daan C.L.; Vermunt, Lisa; Vancura, Adrienne; Muller, Mirte; Niemeijer, Anna-Larissa N.; Tannous, Jihane; Meijer, Laura L.; Le Large, Tessa Y.S.; Mantini, Giulia; Wondergem, Niels E.; Heinhuis, Kimberley M.; van Wilpe, Sandra; Smits, A. Josien; Drees, Esther E.E.; Roos, Eva; Leurs, Cyra E.; Tjon-Kon-Fat, Lee-Ann; van der Lelij, Ewoud J.; Dwarshuis, Govert; Kamphuis, Maarten J.; Visser, Lisanne E.; Harting, Romee; Gregory, Annemijn; Schweiger, Markus W.; Wedekind, Laurine E.; Ramaker, Jip; Zwaan, Kenn; Verschueren, Heleen; Bahce, Idris; de Langen, Adrianus J.; Smit, Egbert F.; van den Heuvel, Michel M.; Hartemink, Koen J.; Kuijpers, Marijke J.E.; oude Egbrink, Mirjam G.A.; Griffioen, Arjan W.; Rossel, Rafael; Hiltermann, T. Jeroen N.; Lee-Lewandrowski, Elizabeth; Lewandrowski, Kent B.; De Witt Hamer, Philip C.; Kouwenhoven, Mathilde; Reijneveld, Jaap C.; Leenders, William P.J.; Hoeben, Ann; Verdonck-de Leeuw, Irma M.; Leemans, C. René; Baatenburg de Jong, Robert J.; Terhaard, Chris H.J.; Takes, Robert P.; Langendijk, Johannes A.; de Jager, Saskia C.; Kraaijeveld, Adriaan O.; Pasterkamp, Gerard; Smits, Minke; Schalken, Jack A.; Łapińska-Szumczyk, Sylwia; Łojkowska, Anna; Żaczek, Anna J.; Lokhorst, Henk; van de Donk, Niels W.C.J.; Nijhof, Inger; Prins, Henk-Jan; Zijlstra, Josée M.; Idema, Sander; Baayen, Johannes C.; Teunissen, Charlotte E.; Killestein, Joep; Besselink, Marc G.; Brammen, Lindsay; Bachleitner-Hofmann, Thomas; Mateen, Farrah; Plukker, John T.M.; Heger, Michal; de Mast, Quirijn; Lisman, Ton; Pegtel, D. Michiel; Bogaard, Harm-Jan; Jassem, Jacek; Supernat, Anna; Mehra, Niven; Gerritsen, Winald; de Kroon, Cornelis D.; Lok, Christianne A.R.; Piek, Jurgen M.J.; Steeghs, Neeltje; van Houdt, Winan J.; Brakenhoff, Ruud H.; Sonke, Gabe S.; Verheul, Henk M.; Giovannetti, Elisa; Kazemier, Geert; Sabrkhany, Siamack; Schuuring, Ed; Sistermans, Erik A.; Wolthuis, Rob; Meijers-Heijboer, Hanne; Dorsman, Josephine; Oudejans, Cees; Ylstra, Bauke; Westerman, Bart A.; van den Broek, Daan; Koppers-Lalic, Danijela; Wesseling, Pieter; Nilsson, R. Jonas A.; Vandertop, W. Peter; Noske, David P.; Tannous, Bakhos A.; Sol, Nik; Best, Myron G.; Wurdinger, Thomas

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Detection and localization of early- and late-stage cancers using platelet RNA

In ’t Veld, Sjors G.J.G.

Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Neurosurgery, Boelelaan 1117, Amsterdam, Netherlands; Cancer Center Amsterdam and Liquid Biopsy Center, Amsterdam, Netherlands; Brain Tumor Center Amsterdam, Amsterdam, Netherlands; Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Clinical Chemistry, Neurochemistry Lab, Boelelaan 1117, Amsterdam, Netherlands; Neuroscience Campus Amsterdam, Amsterdam, Netherlands.

Arkani, Mohammad

Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Neurosurgery, Boelelaan 1117, Amsterdam, Netherlands; Cancer Center Amsterdam and Liquid Biopsy Center, Amsterdam, Netherlands; Brain Tumor Center Amsterdam, Amsterdam, Netherlands; Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Pulmonary Medicine, Boelelaan 1117, Amsterdam, Netherlands.

Post, Edward

Antunes-Ferreira, Mafalda

D'Ambrosi, Silvia

Vessies, Daan C.L.

Vermunt, Lisa

Vancura, Adrienne

Muller, Mirte

Niemeijer, Anna-Larissa N.

Tannous, Jihane

Meijer, Laura L.

Le Large, Tessa Y.S.

Mantini, Giulia

Wondergem, Niels E.

Heinhuis, Kimberley M.

van Wilpe, Sandra

Smits, A. Josien

Drees, Esther E.E.

Roos, Eva

Leurs, Cyra E.

Tjon-Kon-Fat, Lee-Ann

van der Lelij, Ewoud J.

Dwarshuis, Govert

Kamphuis, Maarten J.

Visser, Lisanne E.

Harting, Romee

Gregory, Annemijn

Schweiger, Markus W.

Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Neurosurgery, Boelelaan 1117, Amsterdam, Netherlands; Cancer Center Amsterdam and Liquid Biopsy Center, Amsterdam, Netherlands; Brain Tumor Center Amsterdam, Amsterdam, Netherlands; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MA, Boston, United States; Neuroscience Program, Harvard Medical School, MA, Boston, United States.

Wedekind, Laurine E.

Ramaker, Jip

Zwaan, Kenn

Verschueren, Heleen

Bahce, Idris

de Langen, Adrianus J.

Smit, Egbert F.

van den Heuvel, Michel M.

Hartemink, Koen J.

Kuijpers, Marijke J.E.

oude Egbrink, Mirjam G.A.

Griffioen, Arjan W.

Rossel, Rafael

Hiltermann, T. Jeroen N.

Lee-Lewandrowski, Elizabeth

Lewandrowski, Kent B.

De Witt Hamer, Philip C.

Kouwenhoven, Mathilde

Reijneveld, Jaap C.

Leenders, William P.J.

Hoeben, Ann

Verdonck-de Leeuw, Irma M.

Cancer Center Amsterdam and Liquid Biopsy Center, Amsterdam, Netherlands; Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Otolaryngology and Head and Neck Surgery, Boelelaan 1117, Amsterdam, Netherlands; Department of Clinical, Neuro- and Developmental Psychology, Faculty of Behavioral and Movement Sciences & Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

Leemans, C. René

Baatenburg de Jong, Robert J.

Terhaard, Chris H.J.

Takes, Robert P.

Langendijk, Johannes A.

de Jager, Saskia C.

Kraaijeveld, Adriaan O.

Pasterkamp, Gerard

Smits, Minke

Schalken, Jack A.

Łapińska-Szumczyk, Sylwia

Łojkowska, Anna

Żaczek, Anna J.

Lokhorst, Henk

van de Donk, Niels W.C.J.

Nijhof, Inger

Prins, Henk-Jan

Zijlstra, Josée M.

Idema, Sander

Baayen, Johannes C.

Teunissen, Charlotte E.

Killestein, Joep

Besselink, Marc G.

Brammen, Lindsay

Bachleitner-Hofmann, Thomas

Mateen, Farrah

Plukker, John T.M.

Heger, Michal

de Mast, Quirijn

Lisman, Ton

Pegtel, D. Michiel

Bogaard, Harm-Jan

Jassem, Jacek

Supernat, Anna

Mehra, Niven

Gerritsen, Winald

de Kroon, Cornelis D.

Lok, Christianne A.R.

Piek, Jurgen M.J.

Steeghs, Neeltje

van Houdt, Winan J.

Brakenhoff, Ruud H.

Sonke, Gabe S.

Verheul, Henk M.

Giovannetti, Elisa

Kazemier, Geert

Sabrkhany, Siamack

Schuuring, Ed

Sistermans, Erik A.

Wolthuis, Rob

Meijers-Heijboer, Hanne

Dorsman, Josephine

Oudejans, Cees

Ylstra, Bauke

Westerman, Bart A.

van den Broek, Daan

Koppers-Lalic, Danijela

Wesseling, Pieter

Nilsson, R. Jonas A.

Vandertop, W. Peter

Noske, David P.

Tannous, Bakhos A.

Sol, Nik

Best, Myron G.

Wurdinger, Thomas

Show others and affiliations

2022 (English)In: Cancer Cell, ISSN 1535-6108, E-ISSN 1878-3686, Vol. 40, no 9, p. 999-1009.e6Article in journal (Refereed) Published

Abstract [en]

Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets are involved in cancer progression and are considered a promising biosource for cancer detection, as they alter their RNA content upon local and systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the detection of 18 cancer types. With 99% specificity in asymptomatic controls, thromboSeq correctly detected the presence of cancer in two-thirds of 1,096 blood samples from stage I–IV cancer patients and in half of 352 stage I–III tumors. Symptomatic controls, including inflammatory and cardiovascular diseases, and benign tumors had increased false-positive test results with an average specificity of 78%. Moreover, thromboSeq determined the tumor site of origin in five different tumor types correctly in over 80% of the cancer patients. These results highlight the potential properties of TEP-derived RNA panels to supplement current approaches for blood-based cancer screening.

Place, publisher, year, edition, pages

Elsevier, 2022. Vol. 40, no 9, p. 999-1009.e6

Keywords [en]

blood, blood platelets, cancer, early detection, liquid biopsy, RNA, TEP

National Category

Cancer and Oncology

Identifiers

URN: urn:nbn:se:umu:diva-199458DOI: 10.1016/j.ccell.2022.08.006ISI: 000888756000014PubMedID: 36055228Scopus ID: 2-s2.0-85137385164OAI: oai:DiVA.org:umu-199458DiVA, id: diva2:1699103

Funder

EU, Horizon 2020Available from: 2022-09-27 Created: 2022-09-27 Last updated: 2023-09-05Bibliographically approved

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Tjon-Kon-Fat, Lee-Ann Nilsson, R. Jonas A.

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