Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Changes in perceptual speed and white matter microstructure in the corticospinal tract are associated in very old age
Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Visa övriga samt affilieringar
2014 (Engelska)Ingår i: NeuroImage, ISSN 1053-8119, E-ISSN 1095-9572, Vol. 102, s. 520-530Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The integrity of the brain's white matter is important for neural processing and displays age-related differences, but the contribution of changes in white matter to cognitive aging is unclear. We used latent change modeling to investigate this issue in a sample of very old adults (aged 81-103. years) assessed twice with a retest interval of 2.3. years. Using diffusion-tensor imaging, we probed white matter microstructure by quantifying mean fractional anisotropy and mean diffusivity of six major white matter tracts. Measures of perceptual speed, episodic memory, letter fluency, category fluency, and semantic memory were collected. Across time, alterations of white matter microstructure in the corticospinal tract were associated with decreases of perceptual speed. This association remained significant after statistically controlling for changes in white matter microstructure in the entire brain, in the other demarcated tracts, and in the other cognitive abilities. Changes in brain volume also did not account for the association. We conclude that white matter microstructure is a potent correlate of changes in sensorimotor aspects of behavior in very old age, but that it is unclear whether its impact extends to higher-order cognition.

Ort, förlag, år, upplaga, sidor
Elsevier, 2014. Vol. 102, s. 520-530
Nyckelord [en]
Cognitive aging, Cognitive performance, Longitudinal, Structural equation modeling, White matter microstructure
Nationell ämneskategori
Neurovetenskaper
Identifikatorer
URN: urn:nbn:se:umu:diva-199929DOI: 10.1016/j.neuroimage.2014.08.020ISI: 000345391700026PubMedID: 25139001Scopus ID: 2-s2.0-84906751213OAI: oai:DiVA.org:umu-199929DiVA, id: diva2:1701768
Anmärkning

Part 2.

Tillgänglig från: 2022-10-07 Skapad: 2022-10-07 Senast uppdaterad: 2022-10-07Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMedScopus

Person

Salami, Alireza

Sök vidare i DiVA

Av författaren/redaktören
Salami, Alireza
Av organisationen
Umeå centrum för funktionell hjärnavbildning (UFBI)
I samma tidskrift
NeuroImage
Neurovetenskaper

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 68 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf