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Dual-Task Performance in Older Adults With and Without Idiopathic Normal Pressure Hydrocephalus
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.ORCID-id: 0000-0001-5857-9287
Umeå universitet, Medicinska fakulteten, Umeå centrum för funktionell hjärnavbildning (UFBI). Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB). Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Diagnostisk radiologi. Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway.ORCID-id: 0000-0002-3367-1746
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Psykiatri.ORCID-id: 0000-0001-7868-8894
Department of Medical Sciences, Neurology, Uppsala University, Uppsala, Sweden.ORCID-id: 0000-0002-7504-8354
2022 (Engelska)Ingår i: Frontiers in Aging Neuroscience, ISSN 1663-4365, E-ISSN 1663-4365, Vol. 14, artikel-id 904194Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Two of the main features of idiopathic normal pressure hydrocephalus (iNPH) are disturbed gait and cognition. These features are typically investigated separately, but here we combined walking with a cognitive task to investigate if older adults with iNPH were more susceptible to dual-task interference on walking than those without iNPH. In total, 95 individuals from the general population participated in our study. Of these, 20 were classified as Possible iNPH (median [interquartile range, IQR] 80 years [75–82.5]) and 75 as Unlikely iNPH (74 years [72–78]). Conversation, 10-m walking, semantic and phonemic verbal fluency were performed either combined or independently. “Stopping walking while talking” was noted. Pairwise comparisons and multiple logistic regression analyses were used. We found that the Possible iNPH group was older, stopped walking more frequently during the conversation, and had a slower single-task pace. The dual-task pace was slower for both groups. Only single-task walking pace could predict Possible iNPH when adjusted for age. We could establish a dual-task cost on gait performance in this sample of older adults from the general population, but the cost was not exclusive for individuals with Possible iNPH. To further assess the value of dual-task testing in iNPH, including observations of stopping walking while talking, a study of a clinical iNPH material with more severe symptoms would be valuable.

Ort, förlag, år, upplaga, sidor
Frontiers Media S.A., 2022. Vol. 14, artikel-id 904194
Nyckelord [en]
idiopathic normal pressure hydrocephalus, cognition, dual-task, ageing
Nationell ämneskategori
Neurologi
Forskningsämne
neurologi; klinisk psykologi
Identifikatorer
URN: urn:nbn:se:umu:diva-201140DOI: 10.3389/fnagi.2022.904194ISI: 000810184900001PubMedID: 35707704Scopus ID: 2-s2.0-85132248019OAI: oai:DiVA.org:umu-201140DiVA, id: diva2:1712319
Forskningsfinansiär
Knut och Alice Wallenbergs StiftelseUmeå universitetUppsala universitetRegion Jämtland HärjedalenTillgänglig från: 2022-11-21 Skapad: 2022-11-21 Senast uppdaterad: 2022-11-25Bibliografiskt granskad
Ingår i avhandling
1. A population-based study on neuropsychological and morphological signs of idiopathic normal pressure hydrocephalus
Öppna denna publikation i ny flik eller fönster >>A population-based study on neuropsychological and morphological signs of idiopathic normal pressure hydrocephalus
2022 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

BACKGROUND: Idiopathic normal pressure hydrocephalus (iNPH) is typically manifested in people over 65 years. The condition of gait disturbances, incontinence, and cognitive dysfunction can be reversed in up to 80% of the cases by ventricular shunting. Neuropsychological testing and standardized brain imaging of signs of iNPH are essential to detect and define the progression. The aims of this thesis were to develop a radiological iNPH scale, examine how morphological features relate to symptoms of iNPH, investigate if dual-task testing (e.g., walking and talking) is helpful in detecting iNPH, and monitor developing symptoms over two years.

METHOD: The studies include 168 participants (median [range] age 73 [66–92]) at baseline (2014/2015) and 104 participants (age 75 [68–91]) at follow-up (2016/2017) from the general population. Neuropsychological tests of executive functions, memory, and motor performance, and computed tomography (CT) for brain imaging were used.

RESULTS: Seven morphological features were combined into a scoring scale for iNPH. The total score correlated with clinical symptoms (r = -0.40, p <.001). All core symptoms were associated to wider temporal horns (TH) (p <.01). Participants with iNPH stopped walking to talk more frequently (p = .044). Participants who developed iNPH during the study worsened more on declarative memory (ES -0.37).

DISCUSSION: The Radscale was related to symptoms of iNPH and the TH to all main clinical features. Difficulties walking while recalling a previous event, worsened declarative memory, and expanding ventricular space surrounding the hippocampus were noticeable signs of iNPH. Memory functions are important to recognize in iNPH.

Ort, förlag, år, upplaga, sidor
Umeå: Umeå University, 2022. s. 86
Serie
Umeå University medical dissertations, ISSN 0346-6612 ; 2200
Nyckelord
idiopathic normal pressure hydrocephalus, cognition, dual-task, ageing, temporal horns, morphology, memory, executive function
Nationell ämneskategori
Neurologi
Forskningsämne
neurologi
Identifikatorer
urn:nbn:se:umu:diva-201142 (URN)978-91-7855-889-6 (ISBN)978-91-7855-890-2 (ISBN)
Disputation
2022-12-15, Hörsalen Snäckan, Östersund sjukhus, Östersund, 09:00 (Svenska)
Opponent
Handledare
Tillgänglig från: 2022-11-24 Skapad: 2022-11-21 Senast uppdaterad: 2022-12-02Bibliografiskt granskad

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Lilja-Lund, OttoNyberg, LarsMaripuu, MartinLaurell, Katarina

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NeurovetenskaperUmeå centrum för funktionell hjärnavbildning (UFBI)Institutionen för integrativ medicinsk biologi (IMB)Diagnostisk radiologiPsykiatri
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