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A multimodal ensemble driven by multiobjective optimisation to predict overall survival in non-small-cell lung cancer
Research Unit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, Via Àlvaro del Portillo, 21, Roma, Italy.
Research Unit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, Via Àlvaro del Portillo, 21, Roma, Italy; Department of Computer, Control, and Management Engineering, Sapienza University of Rome, Roma, Italy.
Research Unit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, Via Àlvaro del Portillo, 21, Roma, Italy.
Research Unit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, Via Àlvaro del Portillo, 21, Roma, Italy.
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2022 (English)In: Journal of Imaging, E-ISSN 2313-433X, Vol. 8, no 11, article id 298Article in journal (Refereed) Published
Abstract [en]

Lung cancer accounts for more deaths worldwide than any other cancer disease. In order to provide patients with the most effective treatment for these aggressive tumours, multimodal learning is emerging as a new and promising field of research that aims to extract complementary information from the data of different modalities for prognostic and predictive purposes. This knowledge could be used to optimise current treatments and maximise their effectiveness. To predict overall survival, in this work, we investigate the use of multimodal learning on the CLARO dataset, which includes CT images and clinical data collected from a cohort of non-small-cell lung cancer patients. Our method allows the identification of the optimal set of classifiers to be included in the ensemble in a late fusion approach. Specifically, after training unimodal models on each modality, it selects the best ensemble by solving a multiobjective optimisation problem that maximises both the recognition performance and the diversity of the predictions. In the ensemble, the labels of each sample are assigned using the majority voting rule. As further validation, we show that the proposed ensemble outperforms the models learning a single modality, obtaining state-of-the-art results on the task at hand.

Place, publisher, year, edition, pages
MDPI, 2022. Vol. 8, no 11, article id 298
Keywords [en]
convolutional neural networks, medical imaging, multiexpert systems, multimodal deep learning, oncology, optimisation, precision medicine, tabular data
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-201226DOI: 10.3390/jimaging8110298ISI: 000883971500001PubMedID: 36354871Scopus ID: 2-s2.0-85141759285OAI: oai:DiVA.org:umu-201226DiVA, id: diva2:1716106
Available from: 2022-12-05 Created: 2022-12-05 Last updated: 2023-03-24Bibliographically approved

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Soda, Paolo

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