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Longitudinal stability in working memory and frontal activity in relation to general brain maintenance
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology. Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).ORCID iD: 0000-0002-3367-1746
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).ORCID iD: 0000-0002-8603-9453
Aging Research Center, Karolinska Institutet & Stockholm University, Tomtebodavägen 18A, Stockholm, Sweden.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Aging Research Center, Karolinska Institutet & Stockholm University, Tomtebodavägen 18A, Stockholm, Sweden.
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2022 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 12, no 1, article id 20957Article in journal (Refereed) Published
Abstract [en]

Cognitive functions are well-preserved for some older individuals, but the underlying brain mechanisms remain disputed. Here, 5-year longitudinal 3-back in-scanner and offline data classified individuals in a healthy older sample (baseline age = 64–68 years) into having stable or declining working-memory (WM). Consistent with a vital role of the prefrontal cortex (PFC), WM stability or decline was related to maintained or reduced longitudinal PFC functional responses. Subsequent analyses of imaging markers of general brain maintenance revealed higher levels in the stable WM group on measures of neurotransmission and vascular health. Also, categorical and continuous analyses showed that rate of WM decline was related to global (ventricles) and local (hippocampus) measures of neuronal integrity. Thus, our findings support a role of the PFC as well as general brain maintenance in explaining heterogeneity in longitudinal WM trajectories in aging.

Place, publisher, year, edition, pages
Springer Nature, 2022. Vol. 12, no 1, article id 20957
National Category
Neurosciences
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URN: urn:nbn:se:umu:diva-201756DOI: 10.1038/s41598-022-25503-9ISI: 000984275000060PubMedID: 36470934Scopus ID: 2-s2.0-85143310050OAI: oai:DiVA.org:umu-201756DiVA, id: diva2:1721133
Funder
Knut and Alice Wallenberg FoundationSwedish Research Council, 2018-05973Umeå UniversityRegion VästerbottenThe Swedish Brain Foundation
Note

The freesurfer-analyses were performed on resources provided by the Swedish National Infrastructure for Computing (SNIC) at HPC2N, Umeå University

Available from: 2022-12-21 Created: 2022-12-21 Last updated: 2023-09-05Bibliographically approved

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Nyberg, LarsKaralija, NinaSalami, AlirezaAndersson, MicaelPedersen, RobinVikner, TomasRiklund, KatrineWåhlin, Anders

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Nyberg, LarsKaralija, NinaSalami, AlirezaAndersson, MicaelPedersen, RobinVikner, TomasRiklund, KatrineWåhlin, Anders
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Diagnostic RadiologyDepartment of Integrative Medical Biology (IMB)Umeå Centre for Functional Brain Imaging (UFBI)Radiation PhysicsDepartment of Applied Physics and Electronics
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