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PET/MR versus PET/CT for locoregional staging of oropharyngeal squamous cell cancer
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Diagnostisk radiologi.ORCID-id: 0000-0001-8229-5428
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Diagnostisk radiologi.
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.ORCID-id: 0000-0002-3683-3763
2023 (Engelska)Ingår i: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 64, nr 5, s. 1865-1872Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: The value of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for TN staging in head and neck cancer (HNC) has been proven in numerous studies. A few studies have investigated the value of FDG-PET/magnetic resonance imaging (MRI) in the staging of HNC; the combined results indicate potential for FDG-PET/MRI, but the scientific evidence remains weak.

Purpose: To compare performance of FDG-PET/CT and FDG-PET/MRI for locoregional staging in patients with oropharyngeal carcinomas.

Material and Methods: Two radiologists independently of each other retrospectively reviewed primary pre-therapeutic FDG-PET/CT and FDG-PET/MRI examinations from 40 individuals with oropharyngeal carcinomas. TN stage and primary tumor size were noted. The results were compared between observers and modalities and against TN stage set at a multidisciplinary conference.

Results: For nodal staging, PET/MRI had slightly higher specificity and accuracy than PET/CT for the most experienced observer. Both methods demonstrated excellent sensitivity (≥ 0.97 and 1.00, respectively), as well as high negative predictive values (≥ 0.95 and 1.00, respectively). No significant differences were found for tumor staging or measurement of maximum tumor diameter. There was a weak agreement (κ = 0.35–0.49) between PET/CT and PET/MRI for T and N stages for both observers. Inter-observer agreement was higher for PET/MRI than for PET/CT, both for tumor staging (κ = 0.57 vs. 0.35) and nodal staging (κ = 0.69 vs. 0.55). The agreement between observers was comparable to the agreement between methods.

Conclusion: PET/MRI may be a viable alternative to PET/CT for locoregional staging (TN staging) and assessment of maximal tumor diameter in oropharyngeal squamous cell cancer.

Ort, förlag, år, upplaga, sidor
Sage Publications, 2023. Vol. 64, nr 5, s. 1865-1872
Nyckelord [en]
18F-FDG, cancer staging, Head and neck cancer, positron emission tomography/computed tomography, positron emission tomography/magnetic resonance imaging
Nationell ämneskategori
Radiologi och bildbehandling
Identifikatorer
URN: urn:nbn:se:umu:diva-202001DOI: 10.1177/02841851221140668ISI: 000893509800001PubMedID: 36464816Scopus ID: 2-s2.0-85144223158OAI: oai:DiVA.org:umu-202001DiVA, id: diva2:1722515
Forskningsfinansiär
CancerfondenUmeå universitetRegion Västerbotten, RV-940921Tillgänglig från: 2022-12-29 Skapad: 2022-12-29 Senast uppdaterad: 2023-07-13Bibliografiskt granskad

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