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Erythrocytosis, thrombocytosis, and rate of recurrent thromboembolic event: a population based cohort study
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.ORCID iD: 0000-0002-9984-3520
NU Hospital Group, Uddevalla, Sweden.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.ORCID iD: 0000-0001-6206-3099
Umeå University, Faculty of Medicine, Department of Radiation Sciences.
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2023 (English)In: European Journal of Haematology, ISSN 0902-4441, E-ISSN 1600-0609, Vol. 110, no 6, p. 608-617Article in journal (Refereed) Published
Abstract [en]

Introduction: The management to reduce risk of thromboembolic complications in polycythemia vera and essential thrombocythemia are well established, but for other conditions with elevated hemoglobin, hematocrit, or platelets there are no consensus regarding treatment and follow up.

Aims: To assess frequency of elevated blood values in patients with thromboembolic event, how many of these should be investigated further regarding myeloproliferative neoplasm and if the risk of recurrent event is depending on underlying condition.

Methods: Retrospective cohort study of 3931 adult patients in the county of Norrbotten, Sweden, with thromboembolism during 2017 and 2018.

Results: Of the 3931 patients, 1195 had either elevated Hb, HCT, or platelets fulfilling the 2016 revised WHO criteria for PV and ET, and out of these 411 should be evaluated regarding underlying myeloproliferative neoplasms. Unexplained thrombocytosis and secondary erythrocytosis were associated with the highest rate of recurrent event as well as the most inferior restricted mean survival time.

Conclusion: Elevated blood values are common in patients with thromboembolic event and the high risk of recurrent event and inferior restricted mean survival time in patients with unexplained thrombocytosis and secondary erythrocytosis implicates the importance of finding and managing the underlying condition.

Place, publisher, year, edition, pages
John Wiley & Sons, 2023. Vol. 110, no 6, p. 608-617
Keywords [en]
essential thrombocythemia, polycythemia, polycythemia vera, thrombocytosis, thromboembolism
National Category
Hematology
Identifiers
URN: urn:nbn:se:umu:diva-205189DOI: 10.1111/ejh.13938ISI: 000932888700001PubMedID: 36725666Scopus ID: 2-s2.0-85147986248OAI: oai:DiVA.org:umu-205189DiVA, id: diva2:1739922
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Norrbotten County CouncilAvailable from: 2023-02-28 Created: 2023-02-28 Last updated: 2023-07-12Bibliographically approved

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Enblom, AnneliHolmberg, HenrikLiljeholm, MariaSjälander, Anders

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Department of Public Health and Clinical MedicineDepartment of Radiation Sciences
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