Body weight at age 20 and in midlife is more important than weight gain for coronary atherosclerosis: Results from SCAPIS Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.
Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.
CMIV, Centre of Medical Image Science and Visualization, Linköping University, Linköping, Sweden; Department of Clinical Physiology and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden; Department of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden.
Department of Cardiology, Skåne University Hospital, Malmö, Sweden; Cardiovascular Research Translational Studies, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
Department of Clinical Sciences, Danderyd University Hospital, Karolinska Institutet, Stockholm, Sweden.
Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden; Department of Cardiology, Skåne University Hospital, Malmö, Sweden; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden; Hypertension in Africa Research Team HART, North-West University, Potchefstroom, South Africa.
CMIV, Centre of Medical Image Science and Visualization, Linköping University, Linköping, Sweden; Department of Radiology, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden; Department of Clinical Sciences, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden.
Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden; Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden.
Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.
Department of Medical Sciences, Uppsala University, Uppsala, Sweden; The George Institute for Global Health, University of New South Wales, Sydney, Australia.
Department of Cardiology and Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden.
Section of Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
CMIV, Centre of Medical Image Science and Visualization, Linköping University, Linköping, Sweden; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Department of Medical Sciences, Clinical Epidemiology, Uppsala University, Uppsala, Sweden.
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2023 (Engelska) Ingår i: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 373, s. 46-54Artikel i tidskrift (Refereegranskat) Published
Abstract [en]
Background and aims: Elevated body weight in adolescence is associated with early cardiovascular disease, but whether this association is traceable to weight in early adulthood, weight in midlife or to weight gain is not known. The aim of this study is to assess the risk of midlife coronary atherosclerosis being associated with body weight at age 20, body weight in midlife and body weight change.
Methods: We used data from 25,181 participants with no previous myocardial infarction or cardiac procedure in the Swedish CArdioPulmonary bioImage Study (SCAPIS, mean age 57 years, 51% women). Data on coronary atherosclerosis, self-reported body weight at age 20 and measured midlife weight were recorded together with potential confounders and mediators. Coronary atherosclerosis was assessed using coronary computed tomography angiography (CCTA) and expressed as segment involvement score (SIS).
Results: The probability of having coronary atherosclerosis was markedly higher with increasing weight at age 20 and with mid-life weight (p < 0.001 for both sexes). However, weight increase from age 20 until mid-life was only modestly associated with coronary atherosclerosis. The association between weight gain and coronary atherosclerosis was mainly seen in men. However, no significant sex difference could be detected when adjusting for the 10-year delay in disease development in women.
Conclusions: Similar in men and women, weight at age 20 and weight in midlife are strongly related to coronary atherosclerosis while weight increase from age 20 until midlife is only modestly related to coronary atherosclerosis.
Ort, förlag, år, upplaga, sidor Elsevier, 2023. Vol. 373, s. 46-54
Nyckelord [en]
Coronary artery calcium score, Midlife, Sex, Weight, Weight gain
Nationell ämneskategori
Kardiologi och kardiovaskulära sjukdomar
Identifikatorer URN: urn:nbn:se:umu:diva-205473 DOI: 10.1016/j.atherosclerosis.2023.01.024 ISI: 001010662800001 PubMedID: 36813601 Scopus ID: 2-s2.0-85148722883 OAI: oai:DiVA.org:umu-205473 DiVA, id: diva2:1744107
Forskningsfinansiär Hjärt-Lungfonden Knut och Alice Wallenbergs Stiftelse Vetenskapsrådet Vinnova Göteborgs universitet Karolinska Institutet Linköpings universitet Lunds universitet Umeå universitet Uppsala universitet Hjärt-Lungfonden, 20180324 Vetenskapsrådet, 2019–01140 Vetenskapsrådet, 2018–02527 AFA Försäkring, 160334 2023-03-172023-03-172025-02-10 Bibliografiskt granskad