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The resection rate of synchronously detected liver and lung metastasis from colorectal cancer is low: a national registry-based study
Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Göteborg, Sweden.
Department of Surgery, Skåne University Hospital, Lund University, Lund, Sweden.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences. Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM).ORCID iD: 0000-0003-1732-168x
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2023 (English)In: Cancers, ISSN 2072-6694, Vol. 15, no 5, article id 1434Article in journal (Refereed) Published
Abstract [en]

Population-based data on the incidence and surgical treatment of patients with colorectal cancer (CRC) and synchronous liver and lung metastases are lacking as are real-life data on the frequency of metastasectomy for both sites and outcomes in this setting. This is a nationwide population-based study of all patients having liver and lung metastases diagnosed within 6 months of CRC between 2008 and 2016 in Sweden identified through the merging of data from the National Quality Registries on CRC, liver and thoracic surgery and the National Patient Registry. Among 60,734 patients diagnosed with CRC, 1923 (3.2%) had synchronous liver and lung metastases, of which 44 patients had complete metastasectomy. Surgery of liver and lung metastases yielded a 5-year OS of 74% (95% CI 57–85%) compared to 29% (95% CI 19–40%) if liver metastases were resected but not the lung metastases and 2.6% (95% CI 1.5–4%) if non-resected, p < 0.001. Complete resection rates ranged from 0.7% to 3.8% between the six healthcare regions of Sweden, p = 0.007. Synchronous liver and lung CRC metastases are rare, and a minority undergo the resection of both metastatic sites but with excellent survival. The reasons for differences in regional treatment approaches and the potential of increased resection rates should be studied further.

Place, publisher, year, edition, pages
MDPI, 2023. Vol. 15, no 5, article id 1434
Keywords [en]
colorectal cancer, incidence, liver metastases, lung metastases, synchronous metastases, treatment
National Category
Surgery Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-205928DOI: 10.3390/cancers15051434ISI: 000947693900001PubMedID: 36900225Scopus ID: 2-s2.0-85149850000OAI: oai:DiVA.org:umu-205928DiVA, id: diva2:1746061
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Bengt Ihres FoundationRegion StockholmAvailable from: 2023-03-27 Created: 2023-03-27 Last updated: 2024-01-25Bibliographically approved

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Hemmingsson, Oskar

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