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Reliability and validity of visual analysis of [18F]FE-PE2I PET/CT in early Parkinsonian disease
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Department of Clinical Sciences, Neurosciences.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).ORCID iD: 0000-0002-3731-3612
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology.
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2023 (English)In: Nuclear medicine communications, ISSN 0143-3636, E-ISSN 1473-5628, Vol. 44, no 5, p. 397-406Article in journal (Refereed) Published
Abstract [en]

Objective: [18F]FE-PE2I (FE-PE2I) is a new radiotracer for dopamine transporter (DAT) imaging with PET. The aim of this study was to evaluate the visual interpretation of FE-PE2I images for the diagnosis of idiopathic Parkinsonian syndrome (IPS). The inter-rater variability, sensitivity, specificity, and diagnostic accuracy for visual interpretation of striatal FE-PE2I compared to [123I]FP-CIT (FP-CIT) single-photon emission computed tomography (SPECT) was evaluated.

Methods: Thirty patients with newly onset parkinsonism and 32 healthy controls with both an FE-PE2I and FP-CIT were included in the study. Four patients had normal DAT imaging, of which three did not fulfil the IPS criteria at the clinical reassessment after 2 years. Six raters evaluated the DAT images blinded to the clinical diagnosis, interpreting the image as being ‘normal’ or ‘pathological’, and assessed the degree of DAT-reduction in the caudate and putamen. The inter-rater agreement was assessed with intra-class correlation and Cronbach’s α. For calculation of sensitivity and specificity, DAT images were defined as correctly classified if categorized as normal or pathological by ≥4/6 raters.

Results: The overall agreement in visual evaluation of the FE-PE2I- and FP-CIT images was high for the IPS patients (α = 0.960 and 0.898, respectively), but lower in healthy controls (FE-PE2I: α = 0.693, FP-CIT: α = 0.657). Visual interpretation gave high sensitivity (both 0.96) but lower specificity (FE-PE2I: 0.86, FP-CIT: 0.63) with an accuracy of 90% for FE-PE2I and 77% for FP-CIT.

Conclusion: Visual evaluation of FE-PE2I PET imaging demonstrates high reliability and diagnostic accuracy for IPS.

Place, publisher, year, edition, pages
Wolters Kluwer, 2023. Vol. 44, no 5, p. 397-406
Keywords [en]
[18F]FE-PE2I PET/computed tomography, diagnostic accuracy, early disease, Parkinson’s disease, PET
National Category
Radiology, Nuclear Medicine and Medical Imaging
Research subject
Radiology; Neurology
Identifiers
URN: urn:nbn:se:umu:diva-206635DOI: 10.1097/mnm.0000000000001679ISI: 000970601600009PubMedID: 36862448Scopus ID: 2-s2.0-85152168200OAI: oai:DiVA.org:umu-206635DiVA, id: diva2:1750429
Funder
Region VästerbottenUmeå UniversityParkinsonfondenAvailable from: 2023-04-13 Created: 2023-04-13 Last updated: 2024-07-02Bibliographically approved

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af Bjerkén, SaraAxelsson, JanLarsson, AnneFlygare, CarolinaStrandberg, SaraEriksson, LindaBäckström, David C.Jakobson Mo, Susanna

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af Bjerkén, SaraAxelsson, JanLarsson, AnneFlygare, CarolinaStrandberg, SaraEriksson, LindaBäckström, David C.Jakobson Mo, Susanna
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Department of Integrative Medical Biology (IMB)NeurosciencesRadiation PhysicsUmeå Centre for Functional Brain Imaging (UFBI)Diagnostic Radiology
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Nuclear medicine communications
Radiology, Nuclear Medicine and Medical Imaging

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