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Determining impairment in the Swedish, Polish and German ECAS: the importance of adjusting for age and education
Department of Neurology, Ulm University, Ulm, Germany.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.ORCID-id: 0000-0002-1225-3190
Department of Neurology, University Clinical Centre of Medical University of Warsaw, Warsaw, Poland.
Department of Neurology, Ulm University, Ulm, Germany.
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2023 (Engelska)Ingår i: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, ISSN 2167-8421, E-ISSN 2167-9223, Vol. 24, nr 5-6, s. 475-484Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: Age and years of education are strong predictors of cognitive performance in several versions of the Edinburgh Cognitive and Behavioral ALS Screen (ECAS) and cutoffs for the Swedish and Polish versions are not established yet. Here we evaluated the performance of healthy subjects on the national versions of the Swedish and Polish ECAS and compared cognitive performance on three European translations of the ECAS.

Methods: The ECAS performances of healthy subjects from Sweden (n = 111), Poland (n = 124) and Germany (n = 86) were compared. Based on the test results on the national versions of ECAS, age- and education-adjusted cutoffs were compared for the German, Swedish and Polish versions, respectively.

Results: Age and years of education correlated with performance in the ECAS. Swedish subjects under the age of 60 years and Swedish subjects with low education level scored significantly higher in memory than the respective German and Polish subgroups. German and Polish subjects over 60 years of age performed significantly better in language than the respective Swedish subgroup. The Polish cohort in total had lower executive scores compared to the Swedish cohort, and lower than the German subjects in the higher education subgroup.

Conclusions: The results highlight the importance of establishing age- and education-adjusted ECAS cutoffs not only in general, but also for seemingly similar populations of different origins. The results should be taken into account when comparing cognition data across patient populations including in drug trials where an ECAS test result is being used as an inclusion criterium or outcome measure.

Ort, förlag, år, upplaga, sidor
Taylor & Francis, 2023. Vol. 24, nr 5-6, s. 475-484
Nyckelord [en]
ALS, cognition test, ECAS, FTD, population differences
Nationell ämneskategori
Neurologi
Identifikatorer
URN: urn:nbn:se:umu:diva-206768DOI: 10.1080/21678421.2023.2192248ISI: 000961175100001PubMedID: 36994762Scopus ID: 2-s2.0-85152069229OAI: oai:DiVA.org:umu-206768DiVA, id: diva2:1753430
Forskningsfinansiär
Hjärnfonden, 2013-0279Hjärnfonden, 2016-0303Hjärnfonden, 2018-0310Vetenskapsrådet, 2012-3167Vetenskapsrådet, 2017-03100Knut och Alice Wallenbergs Stiftelse, 2012.0091Knut och Alice Wallenbergs Stiftelse, 2014.0305Region Västerbotten, 2013-7590Tillgänglig från: 2023-04-27 Skapad: 2023-04-27 Senast uppdaterad: 2023-10-06Bibliografiskt granskad

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Winroth, IvarStenberg, Erica A.Häggström, Ann-CristinAndersen, Peter M.

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Winroth, IvarStenberg, Erica A.Häggström, Ann-CristinSemb, OlofAndersen, Peter M.
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NeurovetenskaperPsykiatri
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Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Neurologi

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