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Effects on serum hormone concentrations after a dietary phytoestrogen intervention in patients with prostate cancer: a randomized controlled trial
Department of Oncology, Division of Clinical Cancer Epidemiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Animal and Veterinary Sciences, Aarhus University, AU-Foulum, Tjele, Denmark.
Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Life Sciences, Division of Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden.
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2023 (Engelska)Ingår i: Nutrients, E-ISSN 2072-6643, Vol. 15, nr 7, artikel-id 1792Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Phytoestrogens have been suggested to have an anti-proliferative role in prostate cancer, potentially by acting through estrogen receptor beta (ERβ) and modulating several hormones. We primarily aimed to investigate the effect of a phytoestrogen intervention on hormone concentrations in blood depending on the ERβ genotype. Patients with low and intermediate-risk prostate cancer, scheduled for radical prostatectomy, were randomized to an intervention group provided with soybeans and flaxseeds (∼200 mg phytoestrogens/d) added to their diet until their surgery, or a control group that was not provided with any food items. Both groups received official dietary recommendations. Blood samples were collected at baseline and endpoint and blood concentrations of different hormones and phytoestrogens were analyzed. The phytoestrogen-rich diet did not affect serum concentrations of testosterone, insulin-like growth factor 1, or sex hormone-binding globulin (SHBG). However, we found a trend of decreased risk of increased serum concentration of estradiol in the intervention group compared to the control group but only in a specific genotype of ERβ (p = 0.058). In conclusion, a high daily intake of phytoestrogen-rich foods has no major effect on hormone concentrations but may lower the concentration of estradiol in patients with prostate cancer with a specific genetic upset of ERβ.

Ort, förlag, år, upplaga, sidor
MDPI, 2023. Vol. 15, nr 7, artikel-id 1792
Nyckelord [en]
estradiol, insulin-like growth factor 1, isoflavones, lignans, phytoestrogens, prostate cancer, sex hormone-binding globulin, testosterone
Nationell ämneskategori
Näringslära Cancer och onkologi
Identifikatorer
URN: urn:nbn:se:umu:diva-207703DOI: 10.3390/nu15071792ISI: 000969674300001Scopus ID: 2-s2.0-85152777258OAI: oai:DiVA.org:umu-207703DiVA, id: diva2:1753644
Forskningsfinansiär
Konung Gustaf V:s Jubileumsfond, 2021:353Konung Gustaf V:s Jubileumsfond, 2020:320Konung Gustaf V:s Jubileumsfond, 2019:262Konung Gustaf V:s Jubileumsfond, 2018:206Konung Gustaf V:s Jubileumsfond, 2017:145Konung Gustaf V:s Jubileumsfond, 2016:76Dr P Håkanssons stiftelseKnut och Alice Wallenbergs Stiftelse, 2015.0114Tillgänglig från: 2023-04-28 Skapad: 2023-04-28 Senast uppdaterad: 2024-02-01Bibliografiskt granskad

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Josefsson, Andreas

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Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)Urologi och andrologi
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