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Metabolic compatibility and the rarity of prokaryote endosymbioses
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för matematik och matematisk statistik. Santa Fe Institute, Santa Fe, Argentina.ORCID-id: 0000-0002-6569-5793
Santa Fe Institute, Santa Fe, Argentina.
School of Earth and Space Exploration, Arizona State University, Tempe, Italy.
2023 (Engelska)Ingår i: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 120, nr 17, artikel-id e2206527120Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The evolution of the mitochondria was a significant event that gave rise to the eukaryotic lineage and most large complex life. Central to the origins of the mitochondria was an endosymbiosis between prokaryotes. Yet, despite the potential benefits that can stem from a prokaryotic endosymbiosis, their modern occurrence is exceptionally rare. While many factors may contribute to their rarity, we lack methods for estimating the extent to which they constrain the appearance of a prokaryotic endosymbiosis. Here, we address this knowledge gap by examining the role of metabolic compatibility between a prokaryotic host and endosymbiont. We use genome-scale metabolic flux models from three different collections (AGORA, KBase, and CarveMe) to assess the viability, fitness, and evolvability of potential prokaryotic endosymbioses. We find that while more than half of host-endosymbiont pairings are metabolically viable, the resulting endosymbioses have reduced growth rates compared to their ancestral metabolisms and are unlikely to gain mutations to overcome these fitness differences. In spite of these challenges, we do find that they may be more robust in the face of environmental perturbations at least in comparison with the ancestral host metabolism lineages. Our results provide a critical set of null models and expectations for understanding the forces that shape the structure of prokaryotic life.

Ort, förlag, år, upplaga, sidor
Proceedings of the National Academy of Sciences (PNAS), 2023. Vol. 120, nr 17, artikel-id e2206527120
Nyckelord [en]
endosymbiosis, eukaryogenesis, evolution, metabolic model, prokaryote
Nationell ämneskategori
Evolutionsbiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-207699DOI: 10.1073/pnas.2206527120PubMedID: 37071674Scopus ID: 2-s2.0-85152971782OAI: oai:DiVA.org:umu-207699DiVA, id: diva2:1753659
Forskningsfinansiär
VetenskapsrådetTillgänglig från: 2023-04-28 Skapad: 2023-04-28 Senast uppdaterad: 2023-04-28Bibliografiskt granskad

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