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Latent heterogeneity of muscle-invasive bladder cancer in patient characteristics and survival: a population-based nation-wide study in the Bladder Cancer Data Base Sweden (BladderBaSe)
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin. Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; Translational Oncology & Urology Research (TOUR), School of Cancer and Pharmaceutical Sciences, King's College, London, United Kingdom.ORCID-id: 0000-0001-6808-4405
Saddle Point Science, York, United Kingdom; Saddle Point Science Europe, Nijmegen, Netherlands.
Department of Urology, Skåne University Hospital, Malmö, Sweden; Institution of Translational Medicine, Lund University, Malmö, Sweden.
Saddle Point Science, York, United Kingdom; Saddle Point Science Europe, Nijmegen, Netherlands; Department of Biophysics, Faculty of Science, Donders Institute, Radboud University, Nijmegen, Netherlands.
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2023 (Engelska)Ingår i: Cancer Medicine, E-ISSN 2045-7634, Vol. 12, nr 12, s. 13856-13864Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Patients with muscle-invasive bladder cancer (MIBC) constitute a heterogenous group in terms of patient and tumour characteristics (‘case-mix’) and prognosis. The aim of the current study was to investigate whether differences in survival could be used to separate MIBC patients into separate classes using a recently developed latent class regression method for survival analysis with competing risks.

Methods: We selected all participants diagnosed with MIBC in the Bladder Cancer Data Base Sweden (BladderBase) and analysed inter-patient heterogeneity in risk of death from bladder cancer and other causes.

Results: Using data from 9653 MIBC patients, we detected heterogeneity with six distinct latent classes in the studied population. The largest, and most frail class included 50% of the study population and was characterised by a somewhat larger proportion of women, higher age at diagnosis, more advanced disease and lower probability of curative treatment. Despite this, patients in this class treated with curative intent by radical cystectomy or radiotherapy had a lower association to risk of death. The second largest class included 23% and was substantially less frail as compared to the largest class. The third and fourth class included each around 9%–10%, whereas the fifth and sixth class included each 3%–4% of the population.

Conclusions: Results from the current study are compatible with previous research and the method can be used to adjust comparisons in prognosis between MIBC populations for influential differences in the distribution of sub-classes.

Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2023. Vol. 12, nr 12, s. 13856-13864
Nyckelord [en]
bladder cancer, competing risks, latent class, survival analysis
Nationell ämneskategori
Cancer och onkologi Urologi och njurmedicin
Identifikatorer
URN: urn:nbn:se:umu:diva-207880DOI: 10.1002/cam4.5981ISI: 000977301300001PubMedID: 37096787Scopus ID: 2-s2.0-85153616725OAI: oai:DiVA.org:umu-207880DiVA, id: diva2:1755560
Forskningsfinansiär
Cancerfonden, CAN 2013/472Cancerfonden, CAN 2017/278Tillgänglig från: 2023-05-08 Skapad: 2023-05-08 Senast uppdaterad: 2024-01-17Bibliografiskt granskad

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Häggström, Christel

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