Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Serum neurofilament light as a predictor of outcome in subarachnoid haemorrhage
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.ORCID-id: 0000-0001-8612-7173
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.ORCID-id: 0000-0003-3354-4146
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Neurovetenskaper.ORCID-id: 0000-0003-3528-8502
UmanDiagnostics®, Umeå, Sweden.
Visa övriga samt affilieringar
2023 (Engelska)Ingår i: Acta Neurochirurgica, ISSN 0001-6268, E-ISSN 0942-0940, Vol. 165, nr 10, s. 2793-2800Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Prognostication of clinical outcome in patients suffering from aneurysmal subarachnoid haemorrhage (SAH) is a challenge. There are no biochemical markers in routine use that can aid in prognostication. Neurofilament light (NFL) measured in cerebrospinal fluid (CSF) has been associated with clinical outcome in previous studies.

Objective: To investigate if serum levels of NFL correlate with CSF levels and long-term clinical outcome in patients suffering from SAH.

Methods: We conducted an observational cohort study of 88 patients treated for SAH at Umeå University Hospital in 2014–2018. Serum and CSF samples were analysed using an enzyme-linked immunosorbent assay to quantify NFL levels. Outcome was assessed using Glasgow Outcome Scale Extended and dichotomised as favourable or unfavourable. Differences in NFL levels between outcome groups were analysed using repeated measurements ANOVA. Relationship between CSF and serum NFL levels was analysed using Pearson’s correlation. A multivariate binary logistic regression model and a receiver operation characteristic curve were used to assess the predictive value of serum NFL.

Results: A significant correlation between serum and CSF-NFL levels could be seen (Pearson’s correlation coefficient = 0.7, p <.0001). Mean level of serum NFL was higher in the unfavourable outcome group than the favourable outcome group (p <.0001), in all epochs of SAH, and correlated with initial disease severity on the World Federation of Neurosurgical Societies scale. Serum NFL in the late phase displayed the best predictive potential in a receiver operation characteristic curve analysis (AUC=0.845, p <.0001).

Conclusion: Levels of NFL in serum and CSF are correlated. Early serum NFL levels seem to reflect initial tissue damage and serum NFL levels in the late phase may reflect secondary events such as vasospasm or delayed cerebral ischemia. Serum NFL may be used as a prognostic marker of clinical outcome in SAH.

Ort, förlag, år, upplaga, sidor
Springer, 2023. Vol. 165, nr 10, s. 2793-2800
Nyckelord [en]
Cerebral vasospasm, Glasgow Outcome Scale, Neurofilament protein l, Subarachnoid haemorrhage
Nationell ämneskategori
Neurologi Neurovetenskaper
Identifikatorer
URN: urn:nbn:se:umu:diva-211994DOI: 10.1007/s00701-023-05673-9ISI: 001019458300001PubMedID: 37351672Scopus ID: 2-s2.0-85163214143OAI: oai:DiVA.org:umu-211994DiVA, id: diva2:1782105
Tillgänglig från: 2023-07-12 Skapad: 2023-07-12 Senast uppdaterad: 2023-12-12Bibliografiskt granskad

Open Access i DiVA

fulltext(643 kB)19 nedladdningar
Filinformation
Filnamn FULLTEXT02.pdfFilstorlek 643 kBChecksumma SHA-512
b2f0588bddd9eaa230eed438fedaa91ec769438992b9b33cce210cabc99c2470ef0038d86314c57578c2afaca6cf0f4e0bfef50af7290ccf702807e1c2113b0c
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMedScopus

Person

Johansson, ConnyAineskog, HelenaKoskinen, Lars-Owe D.Lindvall, Peter

Sök vidare i DiVA

Av författaren/redaktören
Johansson, ConnyAineskog, HelenaKoskinen, Lars-Owe D.Lindvall, Peter
Av organisationen
Neurovetenskaper
I samma tidskrift
Acta Neurochirurgica
NeurologiNeurovetenskaper

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 40 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 271 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf