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A Non-Interventional Study on Vismodegib for Basal Cell Carcinoma in Swedish Patients
Skåne University Hospital, Department of Dermatology and Venereology, Lund, Sweden.
Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Dermatology and Venereology, Gothenburg, Sweden.
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper.ORCID-id: 0000-0002-3683-3763
Skåne University Hospital, Department of Dermatology and Venereology, Lund, Sweden.
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2023 (Engelska)Ingår i: Dermatology Practical and Conceptual, E-ISSN 2160-9381, Vol. 13, nr 2, artikel-id e2023211Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Introduction: Real-life data on vismodegib in advanced basal cell carcinoma (aBCC) are limited. Optimal treatment duration is left to the discretion of the physician.

Objectives: To assess the effectiveness, safety and treatment pattern for vismodegib in aBCC in clinical practice.

Methods: In this multicenter, non-interventional, prospective study, 49 Swedish patients planned for vismodegib treatment were included. The treatment pattern observed was treatment until remission, allowing unlimited discontinuations/pauses.

Results: The majority of patients (93.8%), discontinued at least once during the study. Compared to earlier studies there was a decrease of more than 2 months with actual drug intake, reducing the patients burden and costs, at the same time as a high number of responses were seen (87.8%). Median progression-free-survival was 16.7 months, and 90% of the patients were alive at 13.3 months. Ten patients were re-challenged with vismodegib at recurrence or progression, resulting in five partial remissions and three complete remissions.

Conclusions: Clinical response rates with vismodegib for aBCC were comparable to those of similar trials despite a shorter and more intermittent treatment duration. The majority of re-challenges lead to partial or complete remissions.

Ort, förlag, år, upplaga, sidor
Mattioli1885 , 2023. Vol. 13, nr 2, artikel-id e2023211
Nyckelord [en]
cohort-study, effectiveness, Non-interventional, prospective, safety
Nationell ämneskategori
Dermatologi och venereologi Cancer och onkologi
Identifikatorer
URN: urn:nbn:se:umu:diva-212556DOI: 10.5826/dpc.1302a211PubMedID: 37116181Scopus ID: 2-s2.0-85165686443OAI: oai:DiVA.org:umu-212556DiVA, id: diva2:1785920
Tillgänglig från: 2023-08-07 Skapad: 2023-08-07 Senast uppdaterad: 2023-08-07Bibliografiskt granskad

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