In this paper, we present a workflow developed for designing with and scaling-up new materials in architecture through an iterative cycle of materialization and testing. The framework establishes aconnection between design requirements and form, taking advantage of different scales in new materials known as micro, meso, and macroscale in the process of design/manufacture. Different scales when dealing with material systems-especially in those that possess some level of uncertainty in their behavior from the formation process-makeit challenging to deal with the different material variables controlled at each scale. This paper presents a brief review of existing design workflows centered on material properties. We then discuss case studie sand argue for a multi-scale approach for design. Finally, we present the workflow. By implementing the workflow on two case studies, we answer how we can include material scales and their embedded properties as the central part of the design/manufacture process to aid in implementing new materials in architecture. The case studies are a responsive skin system and a free-standing tensile structure incorporating 3D printed wood filament and knitted yarn as the primary material.