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Cumulative incidence of type 1 diabetes in two cohorts of children with different national gluten recommendations in infancy
Department of Clinical Science, Lund University, Lund, Sweden; Children’s Clinic, Vrinnevi Hospital, Norrköping, Sweden.ORCID iD: 0000-0003-4011-0098
Department of Clinical Science, Lund University, Lund, Sweden.ORCID iD: 0000-0002-8636-8804
Umeå University, Faculty of Medicine, Department of Epidemiology and Global Health.ORCID iD: 0000-0002-0457-2175
Paediatric Endocrinology Unit, Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-2560-0569
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2024 (English)In: Acta Diabetologica, ISSN 0940-5429, E-ISSN 1432-5233, Vol. 61, no 1, p. 35-41Article in journal (Refereed) Published
Abstract [en]

Aims: Between 1985 and 1996, Sweden experienced an "epidemic" of celiac disease with a fourfold increase in incidence in young children. Timing and amount of gluten introduced during infancy have been thought to explain this "epidemic". We aimed to study whether the cumulative incidence of type 1 diabetes differs between children born during the "epidemic" compared to children born after.

Methods: This is a national register study in Sweden comparing the cumulative incidence of type 1 diabetes in two birth cohorts of 240 844 children 0-17 years old born 1992-1993, during the "epidemic", and 179 530 children born 1997-1998, after the "epidemic". Children diagnosed with type 1 diabetes were identified using three national registers.

Results: The cumulative incidence of type 1 diabetes by the age of 17 was statistically significantly higher in those born after the "epidemic" 0.77% than in those born during the "epidemic" 0.68% (p < 0.001).

Conclusion: The incidence of type 1 diabetes is higher in those born after the epidemic compared to those born during the epidemic, which does not support the hypothesis that gluten introduction increases the incidence of T1D. Changes in gluten introduction did not halt the increased incidence of type 1 diabetes in Sweden.

Place, publisher, year, edition, pages
Springer, 2024. Vol. 61, no 1, p. 35-41
Keywords [en]
Celiac disease, Early childhood risk factors, Gluten, Infant feeding, Paediatric type 1 diabetes.
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:umu:diva-213517DOI: 10.1007/s00592-023-02168-yISI: 001049930400001PubMedID: 37589890Scopus ID: 2-s2.0-85168120077OAI: oai:DiVA.org:umu-213517DiVA, id: diva2:1791123
Funder
Lund UniversitySwedish Association of Local Authorities and Regions, ALF 2018/2022Available from: 2023-08-24 Created: 2023-08-24 Last updated: 2024-04-19Bibliographically approved

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Norström, FredrikMyléus, Anna

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