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Labor market affiliation of patients with myeloproliferative neoplasms: a population-based matched cohort study
Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University Hospital and Aarhus University, Denmark.ORCID iD: 0000-0002-4938-037X
Department of Hematology, Zealand University Hospital, Denmark.ORCID iD: 0000-0003-2178-0440
Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University Hospital and Aarhus University, Denmark.ORCID iD: 0000-0001-9433-6442
Novartis Sverige AB, Sweden.
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2023 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226XArticle in journal (Refereed) Epub ahead of print
Abstract [en]

Background: Patients with myeloproliferative neoplasms (MPNs) suffer from substantial symptoms and risk of debilitating complications, yet observational data on their labor market affiliation are scarce.

Material and methods: We conducted a descriptive cohort study using data from Danish nationwide registries, including patients diagnosed with MPN in 2010-2016. Each patient was matched with up to ten comparators without MPN on age, sex, level of education, and region of residence. We assessed pre- and post-diagnosis labor market affiliation, defined as working, unemployed, or receiving sickness benefit, disability pension, retirement pension, or other health-related benefits. Labor market affiliation was assessed weekly from two years pre-diagnosis until death, emigration, or 31 December 2018. For patients and comparators, we reported percentage point (pp) changes in labor market affiliation cross-sectionally from week −104 pre-diagnosis to week 104 post-diagnosis.

Results: The study included 3,342 patients with MPN and 32,737 comparators. From two years pre-diagnosis until two years post-diagnosis, a larger reduction in the proportion working was observed among patients than comparators (essential thrombocythemia: 10.2 [95% CI: 6.3–14.1] vs. 6.8 [95% CI: 5.5–8.0] pp; polycythemia vera: 9.6 [95% CI: 5.9–13.2] vs. 7.4 [95% CI: 6.2–8.7] pp; myelofibrosis: 8.1 [95% CI: 3.0–13.2] vs. 5.8 [95% CI: 4.2–7.5] pp; and unclassifiable MPN: 8.0 [95% CI: 3.0–13.0] vs. 7.4 [95% CI: 5.7–9.1] pp). Correspondingly, an increase in the proportion of patients receiving sickness benefits including other health-related benefits was evident around the time of diagnosis.

Conclusion: Overall, we found that Danish patients with essential thrombocythemia, polycythemia vera, myelofibrosis, and unclassifiable MPN had slightly impaired labor market affiliation compared with a population of the same age and sex. From two years pre-diagnosis to two years post-diagnosis, we observed a larger reduction in the proportion of patients with MPN working and a greater proportion receiving sickness benefits compared with matched individuals.

Place, publisher, year, edition, pages
Taylor & Francis, 2023.
National Category
Hematology
Identifiers
URN: urn:nbn:se:umu:diva-214128DOI: 10.1080/0284186x.2023.2251670OAI: oai:DiVA.org:umu-214128DiVA, id: diva2:1794389
Available from: 2023-09-05 Created: 2023-09-05 Last updated: 2023-09-05

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Stenling, Anna

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Skovgaard Svingel, LiseFriis Christensen, SarahKjærsgaard, AndersStenling, AnnaChristiansen, Christian FynboSeverinsen, Marianne TangHagemann Hilsøe, MortenFrederiksen, HenrikBak, MarieMikkelsen, Ellen Margrethe
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