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Assembly and function of the signal recognition particle from archaea
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.ORCID-id: 0000-0003-0124-0199
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
2012 (Engelska)Ingår i: Macromolecular Crystallography / [ed] Carrondo, M., Spadon, P., Dordrecht: Springer, 2012, s. 125-133Kapitel i bok, del av antologi (Refereegranskat)
Abstract [en]

The signal recognition particle (SRP) is a protein-RNA complex that associates with ribosomes to mediate co-translational targeting of membrane and secretory proteins to biological membranes. The universally conserved core of SRP consists of SRP RNA and the SRP54 protein, and plays the key role in signal-sequence recognition and binding to the SRP receptor. Critical for SRP function is communication between the two conserved SRP54 domains, the GTPase- and the M-domain, so that signal-sequence binding at the M domain directs receptor binding at the GTPase domain. The structural basis for signal-sequence binding by SRP and subsequent signaling is still poorly understood. By studying the structures of the SRP RNA in its free form as well as in complex with its different protein partners, we have made steady progress towards the elucidation of structural states of the SRP, using the archaeon Methanococcus jannaschii as model system. Together with other structures of SRP proteins and RNA-protein complexes, these structures provide new insights into the mechanisms of SRP-mediated protein targeting.

Ort, förlag, år, upplaga, sidor
Dordrecht: Springer, 2012. s. 125-133
Serie
NATO Science for Peace and Security Series A: Chemistry and Biology, ISSN 1874-6489
Nyckelord [en]
Methanococcus jannaschii, Protein transport, Signal recognition particle, Signal sequence, X-ray structure
Nationell ämneskategori
Organisk kemi
Identifikatorer
URN: urn:nbn:se:umu:diva-214160DOI: 10.1007/978-94-007-2530-0_12Scopus ID: 2-s2.0-84863378505ISBN: 978-94-007-2529-4 (tryckt)ISBN: 978-94-007-2530-0 (digital)OAI: oai:DiVA.org:umu-214160DiVA, id: diva2:1795240
Tillgänglig från: 2023-09-07 Skapad: 2023-09-07 Senast uppdaterad: 2023-09-07Bibliografiskt granskad

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Sauer-Eriksson, A. ElisabethHuang, ShenghuaHainzl, Tobias

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