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Biphasic patterns of age-related differences in dopamine D1 receptors across the adult lifespan
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology.ORCID iD: 0000-0002-4501-4735
Aging Research Center, Karolinska Institutet & Stockholm University, Tomtebodavägen 18A, Stockholm, Sweden.
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM).
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology.ORCID iD: 0000-0002-8603-9453
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2023 (English)In: Cell Reports, E-ISSN 2211-1247, Vol. 42, no 9, article id 113107Article in journal (Refereed) Published
Abstract [en]

Age-related alterations in D1-like dopamine receptor (D1DR) have distinct implications for human cognition and behavior during development and aging, but the timing of these periods remains undefined. Enabled by a large sample of in vivo assessments (n = 180, age 20 to 80 years of age, 50% female), we discover that age-related D1DR differences pivot at approximately 40 years of age in several brain regions. Focusing on the most age-sensitive dopamine-rich region, we observe opposing pre- and post-forties interrelations among caudate D1DR, cortico-striatal functional connectivity, and memory. Finally, particularly caudate D1DR differences in midlife and beyond, but not in early adulthood, associate with manifestation of white matter lesions. The present results support a model by which excessive dopamine modulation in early adulthood and insufficient modulation in aging are deleterious to brain function and cognition, thus challenging a prevailing view of monotonic D1DR function across the adult lifespan.

Place, publisher, year, edition, pages
2023. Vol. 42, no 9, article id 113107
Keywords [en]
aging, cognition, CP: Neuroscience, dopamine D1, functional connectivity, neuromodulation, protracted development
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-214414DOI: 10.1016/j.celrep.2023.113107Scopus ID: 2-s2.0-85169884676OAI: oai:DiVA.org:umu-214414DiVA, id: diva2:1798213
Funder
Swedish Research Council, 2016-01936Knut and Alice Wallenberg FoundationRiksbankens JubileumsfondAvailable from: 2023-09-18 Created: 2023-09-18 Last updated: 2024-01-17Bibliographically approved

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Johansson, JarkkoPedersen, RobinKaralija, NinaAndersson, MicaelRiklund, KatrineRieckmann, AnnaNyberg, LarsSalami, Alireza

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Johansson, JarkkoPedersen, RobinKaralija, NinaAndersson, MicaelRiklund, KatrineRieckmann, AnnaNyberg, LarsSalami, Alireza
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Umeå Centre for Functional Brain Imaging (UFBI)Diagnostic RadiologyDepartment of Integrative Medical Biology (IMB)Wallenberg Centre for Molecular Medicine at Umeå University (WCMM)
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Cell Reports
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