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Receptor conversion and survival in breast cancer liver metastases
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.ORCID iD: 0000-0003-4059-3368
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
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2023 (English)In: Breast Cancer Research, ISSN 1465-5411, E-ISSN 1465-542X, Vol. 25, no 1, article id 105Article in journal (Refereed) Published
Abstract [en]

Background: Breast cancer liver metastases (BCLM) is a common cause of breast cancer-related death. The prognostic and predictive value of receptor expression and St Gallen classification is challenged by receptor status discordance in distant metastases. The aim of this study was to determine the rate of receptor conversion from breast cancer to BCLM and the impact on survival.

Method: Patients registered with BCLM in two Swedish national cancer registers were recruited retrospectively. Data on receptor expression in primary breast cancer and BCLM were collected, as well as information about predictive factors for survival. The rate of receptor and subtype conversion was analyzed. A Cox regression model was used to investigate predictive factors for survival.

Results: A cohort of 132 patients with BCLM was identified. Estrogen receptor (ER), progesterone receptor (PgR) and HER2 converted in 17, 33 and 10%, respectively. PgR was lost in BCLM while 8/10 HER2 conversions went from negative to positive. The BC subtype was re-classified in 21% of the BCLM. Median survival after BCLM was 13 months and HER2 amplification was associated with improved survival (HR 0.28 CI 0.085–0.90). The highest predictive value (Harrell´s C-index) was obtained when including both BC and BCLM status.

Conclusions: Receptor and subtype conversions are common in BCLM, and a liver biopsy is warranted to tailor BCLM treatment. HER2 amplification is associated with improved survival in a BCLM cohort.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2023. Vol. 25, no 1, article id 105
Keywords [en]
Breast cancer, Estrogen receptor, Human epidermal growth factor receptor 2, Liver metastases, Progesterone receptor
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-214618DOI: 10.1186/s13058-023-01706-4PubMedID: 37705026Scopus ID: 2-s2.0-85171140754OAI: oai:DiVA.org:umu-214618DiVA, id: diva2:1800539
Funder
The Breast Cancer FoundationRegion VästerbottenNorrbotten County CouncilKnut and Alice Wallenberg FoundationSwedish Research CouncilAvailable from: 2023-09-27 Created: 2023-09-27 Last updated: 2024-02-02Bibliographically approved

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Sundén, MarcusLundqvist, RobertAndersson, AnneSund, MalinHemmingsson, Oskar

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Sundén, MarcusLundqvist, RobertAndersson, AnneSund, MalinHemmingsson, Oskar
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SurgeryDepartment of Public Health and Clinical MedicineOncologyDepartment of Surgical and Perioperative SciencesWallenberg Centre for Molecular Medicine at Umeå University (WCMM)
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