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In vivo spontaneous activity and coital-evoked inhibition of mouse accessory olfactory bulb output neurons
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
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2023 (English)In: iScience, E-ISSN 2589-0042 , Vol. 26, no 9, article id 107545Article in journal (Refereed) Published
Abstract [en]

Little is known about estrous effects on brain microcircuits. We examined the accessory olfactory bulb (AOB) in vivo, in anesthetized naturally cycling females, as model microcircuit receiving coital somatosensory information. Whole-cell recordings demonstrate that output neurons are relatively hyperpolarized in estrus and unexpectedly fire high frequency bursts of action potentials. To mimic coitus, a calibrated artificial vagino-cervical stimulation (aVCS) protocol was devised. aVCS evoked stimulus-locked local field responses in the interneuron layer independent of estrous stage. The response is sensitive to α1-adrenergic receptor blockade, as expected since aVCS increases norepinephrine release in AOB. Intriguingly, only in estrus does aVCS inhibit AOB spike output. Estrus-specific output reduction coincides with prolonged aVCS activation of inhibitory interneurons. Accordingly, in estrus the AOB microcircuit sets the stage for coital stimulation to inhibit the output neurons, possibly via high frequency bursting-dependent enhancement of reciprocal synapse efficacy between inter- and output neurons.

Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 26, no 9, article id 107545
Keywords [en]
Behavioral neuroscience, Cell biology, Neuroscience, Sensory neuroscience
National Category
Neurosciences Physiology
Identifiers
URN: urn:nbn:se:umu:diva-214504DOI: 10.1016/j.isci.2023.107545PubMedID: 37664596Scopus ID: 2-s2.0-85170288229OAI: oai:DiVA.org:umu-214504DiVA, id: diva2:1800679
Funder
Knut and Alice Wallenberg Foundation, 2014.0051The Kempe FoundationsAvailable from: 2023-09-27 Created: 2023-09-27 Last updated: 2023-09-27Bibliographically approved

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Lorenzon, PaoloAntos, KamilTripathi, AnushreeVedin, ViktoriaBerghard, AnnaMedini, Paolo

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Lorenzon, PaoloAntos, KamilTripathi, AnushreeVedin, ViktoriaBerghard, AnnaMedini, Paolo
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