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Pregnancy-related maternal physiological adaptations and fetal chemical exposure
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Obstetrics and Gynecology.ORCID iD: 0000-0002-4673-0960
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Obstetrics and Gynecology.ORCID iD: 0000-0002-4988-1967
Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Huddinge, Stockholm, Sweden; Department of Gynecology and Reproductive Medicine, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
2023 (English)In: Molecular and Cellular Endocrinology, ISSN 0303-7207, E-ISSN 1872-8057, Vol. 578, article id 112064Article in journal (Refereed) Published
Abstract [en]

Prenatal life represents a susceptible window of development during which chemical exposures can permanently alter fetal development, leading to an increased likelihood of disease later in life. Therefore, it is essential to assess exposure in the fetus. However, direct assessment in human fetuses is challenging, so most research measures maternal exposure. Pregnancy induces a range of significant physiological changes in women that may affect chemical metabolism and responses. Moreover, placental function, fetal sex, and pregnancy complications may further modify these exposures. The purpose of this narrative review is to give an overview of major pregnancy-related physiological changes, including placental function and impacts of pregnancy complications, to summarize existing studies assessing chemical exposure in human fetal organs, and to discuss possible interactions between physiological changes and exposures. Our review reveals major knowledge gaps in factors affecting fetal chemical exposure, highlighting the need to develop more sophisticated tools for chemical health risk assessment in fetuses.

Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 578, article id 112064
Keywords [en]
Chemical exposure, Endocrine-disrupting chemical, Fetal development, Physiological adaptation, Placenta, Pregnancy complication
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:umu:diva-214608DOI: 10.1016/j.mce.2023.112064PubMedID: 37683908Scopus ID: 2-s2.0-85171170072OAI: oai:DiVA.org:umu-214608DiVA, id: diva2:1800685
Funder
EU, Horizon 2020, EU952516Swedish Research Council Formas, 2018-02280Swedish Research Council Formas, 2020–01621Karolinska InstituteAvailable from: 2023-09-27 Created: 2023-09-27 Last updated: 2023-09-27Bibliographically approved

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Vinnars, Marie-ThereseBixo, Marie

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