Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer
Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Department Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology, Bremen, Germany; Faculty of Human and Health Sciences, University of Bremen, Bremen, Germany.
Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany; Charité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin, Germany.
Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France.
Visa övriga samt affilieringar
2023 (Engelska)Ingår i: BMC Medicine, E-ISSN 1741-7015, Vol. 21, nr 1, artikel-id 391Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Fatty acid binding protein 4 (FABP-4) is a lipid-binding adipokine upregulated in obesity, which may facilitate fatty acid supply for tumor growth and promote insulin resistance and inflammation and may thus play a role in colorectal cancer (CRC) development. We aimed to investigate the association between circulating FABP-4 and CRC and to assess potential causality using a Mendelian randomization (MR) approach.

Methods: The association between pre-diagnostic plasma measurements of FABP-4 and CRC risk was investigated in a nested case-control study in 1324 CRC cases and the same number of matched controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A two-sample Mendelian randomization study was conducted based on three genetic variants (1 cis, 2 trans) associated with circulating FABP-4 identified in a published genome-wide association study (discovery n = 20,436) and data from 58,131 CRC cases and 67,347 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry.

Results: In conditional logistic regression models adjusted for potential confounders including body size, the estimated relative risk, RR (95% confidence interval, CI) per one standard deviation, SD (8.9 ng/mL) higher FABP-4 concentration was 1.01 (0.92, 1.12) overall, 0.95 (0.80, 1.13) in men and 1.09 (0.95, 1.25) in women. Genetically determined higher FABP-4 was not associated with colorectal cancer risk (RR per FABP-4 SD was 1.10 (0.95, 1.27) overall, 1.03 (0.84, 1.26) in men and 1.21 (0.98, 1.48) in women). However, in a cis-MR approach, a statistically significant association was observed in women (RR 1.56, 1.09, 2.23) but not overall (RR 1.23, 0.97, 1.57) or in men (0.99, 0.71, 1.37).

Conclusions: Taken together, these analyses provide no support for a causal role of circulating FABP-4 in the development of CRC, although the cis-MR provides some evidence for a positive association in women, which may deserve to be investigated further.

Ort, förlag, år, upplaga, sidor
BioMed Central (BMC), 2023. Vol. 21, nr 1, artikel-id 391
Nyckelord [en]
Colorectal cancer, FABP-4, Mendelian randomization
Nationell ämneskategori
Cancer och onkologi Medicinsk genetik
Identifikatorer
URN: urn:nbn:se:umu:diva-215878DOI: 10.1186/s12916-023-03104-1PubMedID: 37833736Scopus ID: 2-s2.0-85174314339OAI: oai:DiVA.org:umu-215878DiVA, id: diva2:1808312
Forskningsfinansiär
CancerfondenVetenskapsrådetRegion SkåneRegion VästerbottenTillgänglig från: 2023-10-31 Skapad: 2023-10-31 Senast uppdaterad: 2023-10-31Bibliografiskt granskad

Open Access i DiVA

fulltext(1041 kB)28 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 1041 kBChecksumma SHA-512
4ab4e1798c88a0fb084f90bc209ff9782cb27cea06a20aa1328e93e92f740a03a03d3080c6fd5752364109b259f42acbf23f8098f9576f95498e243cf08ef92f
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMedScopus

Person

van Guelpen, BethanyHarbs, Justin

Sök vidare i DiVA

Av författaren/redaktören
van Guelpen, BethanyHarbs, Justin
Av organisationen
Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)Onkologi
I samma tidskrift
BMC Medicine
Cancer och onkologiMedicinsk genetik

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 28 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 148 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf