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Histopathology-validated lesion detection rates of clinically significant prostate cancer with mpMRI, [68Ga]PSMA-11-PET and [11C]Acetate-PET
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Radiofysik.ORCID-id: 0000-0001-8890-241x
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Diagnostisk radiologi.
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Radiofysik.
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Radiofysik.
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2023 (Engelska)Ingår i: Nuclear medicine communications, ISSN 0143-3636, E-ISSN 1473-5628, Vol. 44, nr 11, s. 997-1004Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: PET/CT and multiparametric MRI (mpMRI) are important diagnostic tools in clinically significant prostate cancer (csPC). The aim of this study was to compare csPC detection rates with [68Ga]PSMA-11-PET (PSMA)-PET, [11C] Acetate (ACE)-PET, and mpMRI with histopathology as reference, to identify the most suitable imaging modalities for subsequent hybrid imaging. An additional aim was to compare inter-reader variability to assess reproducibility.

Methods: During 2016–2019, all study participants were examined with PSMA-PET/mpMRI and ACE-PET/CT prior to radical prostatectomy. PSMA-PET, ACE-PET and mpMRI were evaluated separately by two observers, and were compared with histopathology-defined csPC. Statistical analyses included two-sided McNemar test and index of specific agreement.

Results: Fifty-five study participants were included, with 130 histopathological intraprostatic lesions >0.05 cc. Of these, 32% (42/130) were classified as csPC with ISUP grade ≥2 and volume >0.5 cc. PSMA-PET and mpMRI showed no difference in performance (P = 0.48), with mean csPC detection rate of 70% (29.5/42) and 74% (31/42), respectively, while with ACE-PET the mean csPC detection rate was 37% (15.5/42). Interobserver agreement was higher with PSMA-PET compared to mpMRI [79% (26/33) vs 67% (24/38)]. Including all detected lesions from each pair of observers, the detection rate increased to 90% (38/42) with mpMRI, and 79% (33/42) with PSMA-PET.

Conclusion: PSMA-PET and mpMRI showed high csPC detection rates and superior performance compared to ACE-PET. The interobserver agreement indicates higher reproducibility with PSMA-PET. The combined result of all observers in both PSMA-PET and mpMRI showed the highest detection rate, suggesting an added value of a hybrid imaging approach.

Ort, förlag, år, upplaga, sidor
Lippincott Williams & Wilkins, 2023. Vol. 44, nr 11, s. 997-1004
Nyckelord [en]
acetate-PET, detection rate, intraprostatic lesion, multiparametric MRI, prostate cancer, PSMA-PET
Nationell ämneskategori
Radiologi och bildbehandling
Identifikatorer
URN: urn:nbn:se:umu:diva-216125DOI: 10.1097/MNM.0000000000001743ISI: 001083841200009PubMedID: 37615497Scopus ID: 2-s2.0-85174936230OAI: oai:DiVA.org:umu-216125DiVA, id: diva2:1810038
Forskningsfinansiär
CancerfondenVästerbottens läns landstingTillgänglig från: 2023-11-06 Skapad: 2023-11-06 Senast uppdaterad: 2023-11-06Bibliografiskt granskad

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Sandgren, KristinaStrandberg, SaraJonsson, JoakimGrefve, JosefineKeeratijarut Lindberg, AngsanaNilsson, ErikBergh, AndersSöderkvist, KarinThellenberg-Karlsson, CamillaFriedrich, BengtWidmark, AndersAxelsson, JanÖgren, MattiasÖgren, MargaretaNyholm, TufveRiklund, Katrine

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Sandgren, KristinaStrandberg, SaraJonsson, JoakimGrefve, JosefineKeeratijarut Lindberg, AngsanaNilsson, ErikBergh, AndersSöderkvist, KarinThellenberg-Karlsson, CamillaFriedrich, BengtWidmark, AndersAxelsson, JanÖgren, MattiasÖgren, MargaretaNyholm, TufveRiklund, Katrine
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Nuclear medicine communications
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