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Evolutionary consequences of nascent multicellular life cycles
Los Alamos National Laboratory, Los Alamos, United States.
School of Biological Sciences, Georgia Institute of Technology, Atlanta, United States; Interdisciplinary Graduate Program in Quantitative Biosciences, Georgia Institute of Technology, Atlanta, United States.
School of Biological Sciences, Georgia Institute of Technology, Atlanta, United States.
School of Biological Sciences, Georgia Institute of Technology, Atlanta, United States.
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2023 (Engelska)Ingår i: eLIFE, E-ISSN 2050-084X, Vol. 12, artikel-id e84336Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

A key step in the evolutionary transition to multicellularity is the origin of multicellular groups as biological individuals capable of adaptation. Comparative work, supported by theory, suggests clonal development should facilitate this transition, although this hypothesis has never been tested in a single model system. We evolved 20 replicate populations of otherwise isogenic clonally reproducing 'snowflake' yeast (Δace2/∆ace2) and aggregative 'floc' yeast (GAL1p::FLO1 /GAL1p::FLO1) with daily selection for rapid growth in liquid media, which favors faster cell division, followed by selection for rapid sedimentation, which favors larger multicellular groups. While both genotypes adapted to this regime, growing faster and having higher survival during the group-selection phase, there was a stark difference in evolutionary dynamics. Aggregative floc yeast obtained nearly all their increased fitness from faster growth, not improved group survival; indicating that selection acted primarily at the level of cells. In contrast, clonal snowflake yeast mainly benefited from higher group-dependent fitness, indicating a shift in the level of Darwinian individuality from cells to groups. Through genome sequencing and mathematical modeling, we show that the genetic bottlenecks in a clonal life cycle also drive much higher rates of genetic drift-a result with complex implications for this evolutionary transition. Our results highlight the central role that early multicellular life cycles play in the process of multicellular adaptation.

Ort, förlag, år, upplaga, sidor
eLife Sciences Publications Ltd, 2023. Vol. 12, artikel-id e84336
Nyckelord [en]
adaptation, biological individuality, evolutionary biology, experimental evolution, life cycles, major transitions in evolution, multicellularity, S. cerevisiae
Nationell ämneskategori
Evolutionsbiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-216180DOI: 10.7554/eLife.84336PubMedID: 37889142Scopus ID: 2-s2.0-85175272892OAI: oai:DiVA.org:umu-216180DiVA, id: diva2:1811008
Forskningsfinansiär
NIH (National Institutes of Health), T32GM142616VetenskapsrådetTillgänglig från: 2023-11-10 Skapad: 2023-11-10 Senast uppdaterad: 2023-11-10Bibliografiskt granskad

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Libby, Eric

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