Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Risk of atrial tachycardias after covid-19: nationwide self-controlled cases series and matched cohort study
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.ORCID iD: 0009-0009-8239-2442
Umeå University, Faculty of Medicine, Department of Clinical Microbiology. (Anne-Marie Fors Connolly)ORCID iD: 0000-0002-0253-5928
Umeå University, Faculty of Medicine, Department of Clinical Microbiology. (Anne-Marie Fors Connolly)ORCID iD: 0000-0002-5328-9536
Umeå University, Faculty of Medicine, Department of Clinical Microbiology. (Anne-Marie Fors Connolly)
Show others and affiliations
2023 (English)In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 44, no Suppl. 2, article id ehad655.449Article in journal, Meeting abstract (Refereed) Published
Abstract [en]

Background: COVID-19 is a multiorgan disease. We previously identified COVID-19 as a risk factor for myocardial infarction, stroke (1), venous thromboembolism and bleeding (2). Less evidence exists on the risk of arrhythmias after COVID-19. Previous studies included mainly hospitalized patients with severe COVID-19, and there are no nationwide studies published.

Purpose: The aim of this study was to estimate the risk of atrial tachycardias (atrial fibrillation and atrial flutter) following COVID-19, including all individuals tested positive for SARS-CoV-2 in Sweden, regardless of disease severity.

Method: COVID-19 has been a notifiable disease in Sweden. All individuals in Sweden who were tested positive for SARS-CoV-2 between February 1, 2020 and May 25, 2021 were included in the study. We identified four control individuals for each COVID-19 individual matched on age, sex, and county of residence. Using Personal Identification Numbers, we cross-linked data from national registries: COVID-19 registry; Inpatient and Outpatient Registry; Cause of Death Registry; Prescribed Pharmaceutical Registry and Intensive Care Registry. Outcomes are cardiovascular events, defined using ICD-10 diagnosis codes for atrial fibrillation and atrial flutter in the registries. We performed a ‘’first-ever event’’ analysis, i.e., we excluded individuals with events before the study period. The self-controlled case series (SCCS) method was used to determine the incidence rate ratio (IRR) of a first atrial tachycardia during the risk periods 1-7, 8-14, 15-30, 31-60, 61-90, and 91-180 days after COVID-19. In the matched cohort study (MCS), Poisson regression was performed to calculate the risk ratio (RR) of a first arrhythmia event in the risk period 1-30 days following COVID-19, after adjusting for the effect of confounders, such as cardiac disease, treatment with antiarrhythmics, comorbidities and vaccination status.

Results: 1 057 174 cases and 4 074 844 controls were included in the study. In the SCCS, the risk of first atrial tachycardia was significantly increased up to 60 days following COVID-19. Specifically, during days 1-7 and 8-14 post-COVID-19 the IRRs were approximately 12 and 10 respectively. Similarly, in the MCS the RR for the first atrial tachycardia during day 1-30 post-COVID-19 was approximately 11. The risks were higher in patients with more severe COVID-19; and during the first pandemic wave compared to the second and third wave.

Conclusions: This study suggests that COVID-19 is a risk factor for atrial tachycardias, based on information obtained on all people who tested positive for SARS-CoV-2 in Sweden, regardless of disease severity. These results could impact recommendations on diagnostic and prophylactic strategies against atrial tachycardias after COVID-19. The importance of preventive strategies, such as risk factor control; vaccination to prevent severe COVID-19; and early review of high-risk individuals after COVID-19, is indicated.

Place, publisher, year, edition, pages
Oxford University Press, 2023. Vol. 44, no Suppl. 2, article id ehad655.449
Keywords [en]
COVID-19, SARS-CoV-2, cardiology, arrhythmia, atrial tachycardias, nationwide study, matched cohort study, self-controlled case series study
National Category
Cardiac and Cardiovascular Systems Public Health, Global Health, Social Medicine and Epidemiology Infectious Medicine
Research subject
Epidemiology; Cardiology; Infectious Diseases
Identifiers
URN: urn:nbn:se:umu:diva-216866DOI: 10.1093/eurheartj/ehad655.449OAI: oai:DiVA.org:umu-216866DiVA, id: diva2:1813563
Conference
ESC Congress 2023, Amsterdam, the Netherlands, August 25–28, 2023
Projects
Cardiovascular complications following covid-19: population-based register studiesAvailable from: 2023-11-21 Created: 2023-11-21 Last updated: 2023-11-21Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full text

Authority records

Katsoularis, IoannisFonseca Rodriguez, OsvaldoJerndal, HannaKalucza, SebastianLindmark, KristerFors Connolly, Anne-Marie

Search in DiVA

By author/editor
Katsoularis, IoannisFonseca Rodriguez, OsvaldoJerndal, HannaKalucza, SebastianLindmark, KristerFors Connolly, Anne-Marie
By organisation
Department of Public Health and Clinical MedicineDepartment of Clinical Microbiology
In the same journal
European Heart Journal
Cardiac and Cardiovascular SystemsPublic Health, Global Health, Social Medicine and EpidemiologyInfectious Medicine

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 193 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf