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No moderating influence of education on the association between changes in hippocampus volume and memory performance in aging
Department of Psychology, University of Gothenburg, Gothenburg, Sweden.ORCID iD: 0000-0001-7530-2028
Department of Psychology, University of Gothenburg, Gothenburg, Sweden.
Department of Medicine, Faculty of Medicine and Health Sciences and Institute of Neurosciences, University of Barcelona, Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain.
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology. Danish Research Centre for Magnetic Resonance (DRCMR), Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital – Amager and Hvidovre, Copenhagen, Denmark; Institute for Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark; Institute of Sports Medicine Copenhagen (ISMC) and Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark.ORCID iD: 0000-0002-4458-6475
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2023 (English)In: Aging Brain, ISSN 2589-9589, Vol. 4, article id 100082Article in journal (Refereed) Published
Abstract [en]

Contemporary accounts of factors that may modify the risk for age-related neurocognitive disorders highlight education and its contribution to a cognitive reserve. By this view, individuals with higher educational attainment should show weaker associations between changes in brain and cognition than individuals with lower educational attainment. We tested this prediction in longitudinal data on hippocampus volume and episodic memory from 708 middle-aged and older individuals using local structural equation modeling. This technique does not require categorization of years of education and does not constrain the shape of relationships, thereby maximizing the chances of revealing an effect of education on the hippocampus-memory association. The results showed that the data were plausible under the assumption that there was no influence of education on the association between change in episodic memory and change in hippocampus volume. Restricting the sample to individuals with elevated genetic risk for dementia (APOE ε4 carriers) did not change these results. We conclude that the influence of education on changes in episodic memory and hippocampus volume is inconsistent with predictions by the cognitive reserve theory.

Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 4, article id 100082
Keywords [en]
Cognitive reserve, Brain maintenance, Hippocampus, Memory, Aging
National Category
Psychology (excluding Applied Psychology)
Identifiers
URN: urn:nbn:se:umu:diva-218223DOI: 10.1016/j.nbas.2023.100082OAI: oai:DiVA.org:umu-218223DiVA, id: diva2:1820658
Funder
EU, Horizon 2020, 732592EU, European Research Council, 283634EU, European Research Council, 725025EU, European Research Council, 313440The Research Council of NorwayAvailable from: 2023-12-18 Created: 2023-12-18 Last updated: 2023-12-18Bibliographically approved

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Boraxbekk, Carl-JohanGorbach, TetianaNyberg, Lars

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Lövdén, MartinBoraxbekk, Carl-JohanGorbach, TetianaNyberg, Lars
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Umeå Centre for Functional Brain Imaging (UFBI)Diagnostic RadiologyDepartment of Integrative Medical Biology (IMB)Department of Radiation Sciences
Psychology (excluding Applied Psychology)

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