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Fluoride releasing in polymerblends of poly(ethylene oxide) and poly(methyl methacrylate)
Umeå University, Faculty of Medicine, Department of Odontology.
Umeå University, Faculty of Medicine, Department of Odontology.
Umeå University, Faculty of Medicine, Department of Odontology.
Umeå University, Faculty of Medicine, Department of Odontology.ORCID iD: 0000-0002-1710-7715
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2024 (English)In: Frontiers in Chemistry, E-ISSN 2296-2646, Vol. 12, article id 1356029Article in journal (Refereed) Published
Abstract [en]

Introduction: Polymethyl methacrylate is a polymer commonly used in clinicaldentistry, including denture bases, occlusal splints and orthodontic retainers.

Methods: To augment the polymethyl methacrylate-based dental appliances incounteracting dental caries, we designed a polymer blend film composed ofpolymethyl methacrylate and polyethylene oxide by solution casting and addedsodium fluoride.

Results: Polyethylene oxide facilitated the dispersion of sodium fluoride,decreased the surface average roughness, and positively influenced thehydrophilicity of the films. The blend film made of polymethyl methacrylate,polyethylene oxide and NaF with a mass ratio of 10: 1: 0.3 showed sustainedrelease of fluoride ions and acceptable cytotoxicity. Antibacterial activity of all thefilms to Streptococcus mutans was negligible.

Discussion: This study demonstrated that the polymer blends of polyethyleneoxide and polymethyl methacrylate could realize the relatively steady release offluoride ions with high biocompatibility. This strategy has promising potential toendow dental appliances with anti-cariogenicity.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2024. Vol. 12, article id 1356029
Keywords [en]
dental materials, polymethyl methacrylate, polyethylene oxide, fluoride ion release, polymer blend
National Category
Medical and Health Sciences Dentistry
Identifiers
URN: urn:nbn:se:umu:diva-220718DOI: 10.3389/fchem.2024.1356029Scopus ID: 2-s2.0-85185521631OAI: oai:DiVA.org:umu-220718DiVA, id: diva2:1836516
Funder
Region Västerbotten, RV-937838The Kempe Foundations, JCSMK22-0122The Kempe Foundations, SMK-21-0015Swedish Research Council, 2021-04778Swedish Research Council, 2020-04437Available from: 2024-02-09 Created: 2024-02-09 Last updated: 2024-02-29Bibliographically approved

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Wang, TianxiaoLi, MenghongGu, ZiyanQu, ChengjuanSegervald, JonasSalh, RoushdeyWågberg, ThomasWang, JiaKou, Wen

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Wang, TianxiaoLi, MenghongGu, ZiyanQu, ChengjuanSegervald, JonasSalh, RoushdeyWågberg, ThomasWang, JiaKou, Wen
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Department of OdontologyDepartment of Physics
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Frontiers in Chemistry
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