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Antimicrobial activity of two different types of silver nanoparticles against wide range of pathogenic bacteria
Medical Institute, Sumy State University, 2, Rymskogo-Korsakova St, Sumy, Ukraine.
Medical Institute, Sumy State University, 2, Rymskogo-Korsakova St, Sumy, Ukraine; Faculty of Chemistry, Silesian University of Technology, Gliwice, Poland.
Medical Institute, Sumy State University, 2, Rymskogo-Korsakova St, Sumy, Ukraine; Institute of Atomic Physics and Spectroscopy, University of Latvia, 3 Jelgavas St, Riga, Latvia.
Medical Institute, Sumy State University, 2, Rymskogo-Korsakova St, Sumy, Ukraine.
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2024 (Engelska)Ingår i: Nanomaterials, E-ISSN 2079-4991, Vol. 14, nr 2, artikel-id 137Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The emergence of antibiotic-resistant bacteria, particularly the most hazardous pathogens, namely Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. (ESKAPE)-pathogens pose a significant threat to global health. Current antimicrobial therapies, including those targeting biofilms, have shown limited effectiveness against these superbugs. Nanoparticles, specifically silver nanoparticles (AgNPs), have emerged as a promising alternative for combating bacterial infections. In this study, two types of AgNPs with different physic-chemical properties were evaluated for their antimicrobial and antibiofilm activities against clinical ESKAPE strains. Two types of silver nanoparticles were assessed: spherical silver nanoparticles (AgNPs-1) and cubic-shaped silver nanoparticles (AgNPs-2). AgNPs-2, characterized by a cubic shape and higher surface-area-to-volume ratio, exhibited superior antimicrobial activity compared to spherical AgNPs-1. Both types of AgNPs demonstrated the ability to inhibit biofilm formation and disrupt established biofilms, leading to membrane damage and reduced viability of the bacteria. These findings highlight the potential of AgNPs as effective antibacterial agents against ESKAPE pathogens, emphasizing the importance of nanoparticle characteristics in determining their antimicrobial properties. Further research is warranted to explore the underlying mechanisms and optimize nanoparticle-based therapies for the management of infections caused by antibiotic-resistant bacteria.

Ort, förlag, år, upplaga, sidor
MDPI, 2024. Vol. 14, nr 2, artikel-id 137
Nyckelord [en]
antibiofilm activity, antimicrobial activity, ESKAPE pathogens, silver nanoparticles
Nationell ämneskategori
Mikrobiologi inom det medicinska området
Identifikatorer
URN: urn:nbn:se:umu:diva-220311DOI: 10.3390/nano14020137ISI: 001151533400001Scopus ID: 2-s2.0-85183090925OAI: oai:DiVA.org:umu-220311DiVA, id: diva2:1837406
Forskningsfinansiär
EU, Horisont Europa, 101086441Tillgänglig från: 2024-02-13 Skapad: 2024-02-13 Senast uppdaterad: 2024-02-13Bibliografiskt granskad

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Butsyk, AnnaBoren, Thomas

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Mikrobiologi inom det medicinska området

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