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An electroencephalography-based approach to evaluate movement-related anxiety in physically active adults and following anterior cruciate ligament injury
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Section of Physiotherapy. (U-Motion Laboratory)ORCID iD: 0000-0003-3219-6493
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Section of Physiotherapy.ORCID iD: 0000-0002-6715-6208
Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.ORCID iD: 0000-0003-1098-0076
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Section of Physiotherapy.ORCID iD: 0000-0003-0626-3154
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2022 (English)Conference paper, Poster (with or without abstract) (Refereed)
Abstract [en]

Background: Psychophysiological consequences often persist following musculoskeletal trauma and can result in vastly decreased quality of life. Re-injury anxiety is particularly common among individuals following anterior cruciate ligament (ACL) injury. Existing assessments of re-injury anxiety are, however, restricted to subjective suboptimal questionnaires, which may result in under-reporting and thus poorer injury management. We propose a novel approach to objectively quantify arousal response to movement-related anxiety. A new experimental paradigm was implemented to induce and record a conditioned electrophysiological response to a sudden perturbation, experienced to be potentially injurious.

Objective: To explore the feasibility of detecting anxiety-associated electrocortical response and to evaluate its discriminative ability between asymptomatic individuals and those who had experienced an ACL injury.

Methods: Physically-active asymptomatic persons and individuals post-ACL reconstruction stood blindfolded on a perturbation platform capable of generating high-acceleration translations (1.5 m/s2). Auditory stimuli were repeatedly presented in four-second intervals, as either low- or high-frequency tones. Half of the high-frequency tones were followed 1.5 seconds later by a destabilizing perturbation in one of eight randomized directions. The two tone conditions were thus termed ‘Neutral’ and ‘Anxiety’, as the high-frequency tone was intended to invoke an arousal response in anticipation of a potential perturbation. Event-related potentials (ERP) were computed for nine electrodes by averaging 100 Neutral and 100 Anxiety trials. Significant ERP components were identified using functional data analysis. Paired difference-waves’ amplitudes (Neutral - Anxiety) were compared between groups.

Results: ERP correlates of anxiety were detected for both groups in frontal and central midline locations, with an observable contingent negative variation (CNV) from 500 ms post-stimulus in Anxiety compared with Neutral trials. This ERP component is reflective of a threat-induced arousal response, associated with attention and expectancy of an anxiety-relevant event. Preliminary data indicate no group differences in CNV amplitudes.

Conclusions: Objective evaluation of an arousal response to movement-related anxiety was found to be feasible, resulting in a threat-induced CNV. Further investigation will elucidate the discriminative power of such an approach to differentiate between individuals with high and low re-injury anxiety, as well as potential associations with existing patient-reported outcome measures.

Place, publisher, year, edition, pages
2022. article id 84186
National Category
Health Sciences Psychology
Research subject
Physiotherapy
Identifiers
URN: urn:nbn:se:umu:diva-223317OAI: oai:DiVA.org:umu-223317DiVA, id: diva2:1851291
Conference
Society for Neuroscience 2022 Meeting, San Diego, Carliforna, USA, November 12-16, 2022
Available from: 2024-04-12 Created: 2024-04-12 Last updated: 2024-04-15Bibliographically approved

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Grinberg, AdamStrong, AndrewStrandberg, JohanSelling, JonasLiebermann, Dario G.Björklund, MartinHäger, Charlotte

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Grinberg, AdamStrong, AndrewStrandberg, JohanSelling, JonasLiebermann, Dario G.Björklund, MartinHäger, Charlotte
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Section of PhysiotherapyDepartment of Mathematics and Mathematical StatisticsDepartment of Community Medicine and Rehabilitation
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CiteExportLink to record
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