Short-chain fatty acids (SCFA) in infants’ plasma and corresponding mother's milk and plasma in relation to subsequent sensitisation and atopic disease Visa övriga samt affilieringar
2024 (Engelska) Ingår i: EBioMedicine, E-ISSN 2352-3964, Vol. 101, artikel-id 104999Artikel i tidskrift (Refereegranskat) Published
Abstract [en]
Background: Short-chain fatty acids (SCFAs) in intestinal contents may influence immune function, while less is known about SCFAs in blood plasma. The aims were to investigate the relation between infants’ and maternal plasma SCFAs, as well as SCFAs in mother's milk, and relate SCFA concentrations in infant plasma to subsequent sensitisation and atopic disease.
Methods: Infant plasma (N = 148) and corresponding mother's milk and plasma were collected four months postpartum. Nine SCFA (formic, acetic, propionic, isobutyric, butyric, succinic, valeric, isovaleric, and caproic acid) were analysed by UPLC-MS. At 12 months of age, atopic disease was diagnosed by a pediatric allergologist, and sensitisation was measured by skin prick test. All families participated in the Swedish birth cohort NICE (Nutritional impact on Immunological maturation during Childhood in relation to the Environment).
Findings: Infants with sensitisation, atopic eczema, or food allergy had significantly lower concentrations of five, three, and two SCFAs, respectively, in plasma at four months. Logistic regressions models showed significant negative associations between formic, succinic, and caproic acid and sensitisation [ORadj (95% CI) per SD: 0.41 (0.19–0.91); 0.19 (0.05–0.75); 0.25 (0.09–0.66)], and between acetic acid and atopic eczema [0.42 (0.18–0.95)], after adjusting for maternal allergy. Infants’ and maternal plasma SCFA concentrations correlated strongly, while milk SCFA concentrations were unrelated to both. Butyric and caproic acid concentrations were enriched around 100-fold, and iso-butyric and valeric acid around 3-5-fold in mother's milk, while other SCFAs were less prevalent in milk than in plasma.
Interpretation: Butyric and caproic acid might be actively transported into breast milk to meet the needs of the infant, although mechanistic studies are needed to confirm this. The negative associations between certain SCFAs on sensitisation and atopic disease adds to prior evidence regarding their immunoregulatory potential.
Funding: Swedish Research Council (Nr. 2013-3145 and 2019-0137 to A-S.S.), Swedish Research Council for Health, Working Life and Welfare FORTE, Nr 2018-00485 to A.W.), The Swedish Asthma and Allergy Association's Research Fund (2020-0020 to A.S.).
Ort, förlag, år, upplaga, sidor Elsevier, 2024. Vol. 101, artikel-id 104999
Nyckelord [en]
Atopic eczema, Breast milk, Food allergy, Infant/maternal plasma, Sensitisation, Short-chain fatty acids
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Näringslära
Identifikatorer URN: urn:nbn:se:umu:diva-222658 DOI: 10.1016/j.ebiom.2024.104999 ISI: 001184382900001 PubMedID: 38340558 Scopus ID: 2-s2.0-85184766513 OAI: oai:DiVA.org:umu-222658 DiVA, id: diva2:1852794
Forskningsfinansiär Vetenskapsrådet, 2013-3145 Vetenskapsrådet, 2019-0137 Vetenskapsrådet, 2023-02217 Forte, Forskningsrådet för hälsa, arbetsliv och välfärd, 2018-00485 Astma- och Allergiförbundet, 2020-0020 2024-04-192024-04-192024-04-19 Bibliografiskt granskad