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Dopamine D1-receptor organization contributes to functional brain architecture
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).ORCID iD: 0000-0003-4139-2461
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).ORCID iD: 0000-0002-4501-4735
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Aging Research Center, Karolinska Institutet, Sweden; Stockholm University, Stockholm, Sweden.ORCID iD: 0000-0003-4157-1638
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Radiation Sciences. Max-Planck-Institut für Sozialrecht und Sozialpolitik, Munich, Germany.ORCID iD: 0000-0002-5389-1578
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2024 (English)In: Journal of Neuroscience, ISSN 0270-6474, E-ISSN 1529-2401, Vol. 44, no 11, article id e0621232024Article in journal (Refereed) Published
Abstract [en]

Recent work has recognized a gradient-like organization in cortical function, spanning from primary sensory to transmodal cortices. It has been suggested that this axis is aligned with regional differences in neurotransmitter expression. Given the abundance of dopamine D1-receptors (D1DR), and its importance for modulation and neural gain, we tested the hypothesis that D1DR organization is aligned with functional architecture, and that inter-regional relationships in D1DR co-expression modulate functional cross talk. Using the world's largest dopamine D1DR-PET and MRI database (N = 180%, 50% female), we demonstrate that D1DR organization follows a unimodal–transmodal hierarchy, expressing a high spatial correspondence to the principal gradient of functional connectivity. We also demonstrate that individual differences in D1DR density between unimodal and transmodal regions are associated with functional differentiation of the apices in the cortical hierarchy. Finally, we show that spatial co-expression of D1DR primarily modulates couplings within, but not between, functional networks. Together, our results show that D1DR co-expression provides a biomolecular layer to the functional organization of the brain.

Place, publisher, year, edition, pages
Society for Neuroscience , 2024. Vol. 44, no 11, article id e0621232024
Keywords [en]
architecture, dopamine, functional connectivity, gradients, organization
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-222641DOI: 10.1523/JNEUROSCI.0621-23.2024PubMedID: 38302439Scopus ID: 2-s2.0-85187783583OAI: oai:DiVA.org:umu-222641DiVA, id: diva2:1852825
Available from: 2024-04-19 Created: 2024-04-19 Last updated: 2024-07-02Bibliographically approved

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Pedersen, RobinJohansson, JarkkoNordin, KristinRieckmann, AnnaWåhlin, AndersNyberg, LarsSalami, Alireza

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Pedersen, RobinJohansson, JarkkoNordin, KristinRieckmann, AnnaWåhlin, AndersNyberg, LarsSalami, Alireza
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Department of Integrative Medical Biology (IMB)Wallenberg Centre for Molecular Medicine at Umeå University (WCMM)Umeå Centre for Functional Brain Imaging (UFBI)Department of Radiation Sciences
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