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Microbiological assessment of success and failure in pulp revitalization: a randomized clinical trial using calcium hydroxide and chlorhexidine gluconate in traumatized immature necrotic teeth
Division of Orthodontics and Paediatric Dentistry, Department of Dental Medicine, Karolinska Institute, Stockholm, Sweden; Department of Endodontics, Public Dental Health Services, Stockholm, Eastmaninstitutet, Sweden; Centre of Paediatric Oral Health, Huddinge, Sweden.
Umeå universitet, Medicinska fakulteten, Institutionen för odontologi. Umeå universitet, Medicinska fakulteten, Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM).ORCID-id: 0000-0002-5674-8179
Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.ORCID-id: 0000-0002-3536-4467
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för fysiologisk botanik. Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Umeå Plant Science Centre (UPSC).
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2024 (Engelska)Ingår i: Journal of Oral Microbiology, E-ISSN 2000-2297, Vol. 16, nr 1, artikel-id 2343518Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Aim: To compare differences in the disinfection efficacy of calcium hydroxide (CH) and chlorhexidine gluconate (CHD) dressings in pulp revitalization (PR) of traumatized immature necrotic teeth; to investigate the microflora in successful/failed PR and whether bacterial persistence influences the outcomes of PR.

Methods: Microbiological assessment of the average bacterial load (CFU/sample) and bacterial diversity (taxa/sample) was performed on 41 teeth at three timepoints (S2-before, S3-after debridement and S5- after root canal dressing).

Results: The primary microflora was more diverse in successful cases than in failed. Decreases in CFU/sample and taxa/sample occurred S2 - S3, though new increases occurred at S5 in the CHD subgroup (successful and failed) and CFU/sample in the CH subgroup (failed). At S5, the successful cases showed more bacterial decreases. No specific species was associated with the outcomes with no statistical differences between the disinfection efficacy.

Conclusions: There were no statistical differences in CH and CHD efficacy. At S5, microflora persisted in both successful and failed outcomes, but the abundance and diversity increased significantly only in the failed cases. The successful outcomes presented higher diversity and higher decreases of the primary microflora at S5 than the failed outcomes. The abundance and diversity increased significantly at S5 only in failed cases.

Ort, förlag, år, upplaga, sidor
Taylor & Francis Group, 2024. Vol. 16, nr 1, artikel-id 2343518
Nyckelord [en]
calcium hydroxide, chlorhexidine gluconate, dental trauma, endodontic pulp revitalization, immature traumatized necrotic teeth, microbiological assessment
Nationell ämneskategori
Odontologi
Identifikatorer
URN: urn:nbn:se:umu:diva-223944DOI: 10.1080/20002297.2024.2343518ISI: 001207663700001PubMedID: 38665416Scopus ID: 2-s2.0-85191169436OAI: oai:DiVA.org:umu-223944DiVA, id: diva2:1855826
Forskningsfinansiär
Region StockholmKarolinska InstitutetKnut och Alice Wallenbergs Stiftelse, 396168403Region Västerbotten, 396168402Region Västerbotten, 7002665Tillgänglig från: 2024-05-03 Skapad: 2024-05-03 Senast uppdaterad: 2024-05-03Bibliografiskt granskad

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Romani Vestman, NellyRakhimova, OlenaLazaro Gimeno, DavidBrundin, Malin

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Romani Vestman, NellyRakhimova, OlenaLazaro Gimeno, DavidBrundin, Malin
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Institutionen för odontologiWallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)Institutionen för fysiologisk botanikUmeå Plant Science Centre (UPSC)
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Journal of Oral Microbiology
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