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Maternal age is related to offspring DNA methylation: a meta-analysis of results from the pace consortium
Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, MD, Bethesda, United States.
Division of Intramural Research, Glotech Inc., Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, MD, Bethesda, United States.
ISGlobal, Institute for Global Health, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
MRC Unit the Gambia at the London School of Hygiene and Tropical Medicine (LSHTM), Banjul, Gambia.
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2024 (Engelska)Ingår i: Aging Cell, ISSN 1474-9718, E-ISSN 1474-9726, artikel-id e14194Artikel i tidskrift (Refereegranskat) Epub ahead of print
Abstract [en]

Worldwide trends to delay childbearing have increased parental ages at birth. Older parental age may harm offspring health, but mechanisms remain unclear. Alterations in offspring DNA methylation (DNAm) patterns could play a role as aging has been associated with methylation changes in gametes of older individuals. We meta-analyzed epigenome-wide associations of parental age with offspring blood DNAm of over 9500 newborns and 2000 children (5–10 years old) from the Pregnancy and Childhood Epigenetics consortium. In newborns, we identified 33 CpG sites in 13 loci with DNAm associated with maternal age (PFDR < 0.05). Eight of these CpGs were located near/in the MTNR1B gene, coding for a melatonin receptor. Regional analysis identified them together as a differentially methylated region consisting of 9 CpGs in/near MTNR1B, at which higher DNAm was associated with greater maternal age (PFDR = 6.92 × 10−8) in newborns. In childhood blood samples, these differences in blood DNAm of MTNR1B CpGs were nominally significant (p < 0.05) and retained the same positive direction, suggesting persistence of associations. Maternal age was also positively associated with higher DNA methylation at three CpGs in RTEL1-TNFRSF6B at birth (PFDR < 0.05) and nominally in childhood (p < 0.0001). Of the remaining 10 CpGs also persistent in childhood, methylation at cg26709300 in YPEL3/BOLA2B in external data was associated with expression of ITGAL, an immune regulator. While further study is needed to establish causality, particularly due to the small effect sizes observed, our results potentially support offspring DNAm as a mechanism underlying associations of maternal age with child health.

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John Wiley & Sons, 2024. artikel-id e14194
Nyckelord [en]
aging, child, DNA methylation, melatonin, receptor
Nationell ämneskategori
Pediatrik
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URN: urn:nbn:se:umu:diva-225931DOI: 10.1111/acel.14194ISI: 001234420300001PubMedID: 38808605Scopus ID: 2-s2.0-85194821046OAI: oai:DiVA.org:umu-225931DiVA, id: diva2:1869025
Tillgänglig från: 2024-06-12 Skapad: 2024-06-12 Senast uppdaterad: 2024-06-12

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Harbs, JustinDomellöf, MagnusWest, Christina E.Harlid, Sophia

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