Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology
Department of Neurology, Miller School of Medicine, University of Miami, FL, Miami, United States.
Department of Neurology, Miller School of Medicine, University of Miami, FL, Miami, United States.
Department of Psychiatry and Human Behaviour, Alpert Medical School of Brown University, RI, Providence, United States.
Department of Neurology, University of Pennsylvania Perelman School of Medicine, PA, Philadelphia, United States.
Visa övriga samt affilieringar
2024 (Engelska)Ingår i: Nature Reviews Neurology, ISSN 1759-4758, E-ISSN 1759-4766, Vol. 20, nr 6, s. 364-376Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

Increasing appreciation of the phenotypic and biological overlap between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, alongside evolving biomarker evidence for a pre-symptomatic stage of disease and observations that this stage of disease might not always be clinically silent, is challenging traditional views of these disorders. These advances have highlighted the need to adapt ingrained notions of these clinical syndromes to include both the full phenotypic continuum - from clinically silent, to prodromal, to clinically manifest - and the expanded phenotypic spectrum that includes ALS, frontotemporal dementia and some movement disorders. The updated clinical paradigms should also align with our understanding of the biology of these disorders, reflected in measurable biomarkers. The Miami Framework, emerging from discussions at the Second International Pre-Symptomatic ALS Workshop in Miami (February 2023; a full list of attendees and their affiliations appears in the Supplementary Information) proposes a classification system built on: first, three parallel phenotypic axes - motor neuron, frontotemporal and extrapyramidal - rather than the unitary approach of combining all phenotypic elements into a single clinical entity; and second, biomarkers that reflect different aspects of the underlying pathology and biology of neurodegeneration. This framework decouples clinical syndromes from biomarker evidence of disease and builds on experiences from other neurodegenerative diseases to offer a unified approach to specifying the pleiotropic clinical manifestations of disease and describing the trajectory of emergent biomarkers.

Ort, förlag, år, upplaga, sidor
Springer Nature, 2024. Vol. 20, nr 6, s. 364-376
Nationell ämneskategori
Neurologi
Identifikatorer
URN: urn:nbn:se:umu:diva-226161DOI: 10.1038/s41582-024-00961-zISI: 001228193200001PubMedID: 38769202Scopus ID: 2-s2.0-85195328165OAI: oai:DiVA.org:umu-226161DiVA, id: diva2:1871417
Anmärkning

Erratum:  Benatar, M., Wuu, J., Huey, E.D. et al. The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology. Nat Rev Neurol 20 (6), 377 (2024). https://doi.org/10.1038/s41582-024-00961-z

Tillgänglig från: 2024-06-17 Skapad: 2024-06-17 Senast uppdaterad: 2024-06-17Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMedScopus

Person

Andersen, Peter M.

Sök vidare i DiVA

Av författaren/redaktören
Andersen, Peter M.
Av organisationen
Neurovetenskaper
I samma tidskrift
Nature Reviews Neurology
Neurologi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 33 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf