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Management of patients with advanced prostate cancer. Report from the 2024 advanced prostate cancer consensus conference (APCCC)
Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland; Faculty of Biosciences, Università della Svizzera Italiana, Lugano, Switzerland.
Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
Monash University, Melbourne, Australia; Eastern Health, Melbourne, Australia.
Massachusetts General Hospital, Harvard Medical School, MA, Boston, United States.
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2024 (Engelska)Ingår i: European Urology, ISSN 0302-2838, E-ISSN 1873-7560Artikel i tidskrift (Refereegranskat) Epub ahead of print
Abstract [en]

Background and objective: Innovations have improved outcomes in advanced prostate cancer (PC). Nonetheless, we continue to lack high-level evidence on a variety of topics that greatly impact daily practice. The 2024 Advanced Prostate Cancer Consensus Conference (APCCC) surveyed experts on key questions in clinical management in order to supplement evidence-based guidelines. Here we present voting results for questions from APCCC 2024.

Methods: Before the conference, a panel of 120 international PC experts used a modified Delphi process to develop 183 multiple-choice consensus questions on eight different topics. Before the conference, these questions were administered via a web-based survey to the voting panel members (“panellists”).

Key findings and limitations: Consensus was a priori defined as ≥75% agreement, with strong consensus defined as ≥90% agreement. The voting results show varying degrees of consensus, as discussed in this article and detailed in the Supplementary material. These findings do not include a formal literature review or meta-analysis.

Conclusions and clinical implications: The voting results can help physicians and patients navigate controversial areas of clinical management for which high-level evidence is scant or conflicting. The findings can also help funders and policymakers in prioritising areas for future research. Diagnostic and treatment decisions should always be individualised on the basis of patient and cancer characteristics, and should incorporate current and emerging clinical evidence, guidelines, and logistic and economic factors. Enrolment in clinical trials is always strongly encouraged. Importantly, APCCC 2024 once again identified important gaps (areas of nonconsensus) that merit evaluation in specifically designed trials.

Ort, förlag, år, upplaga, sidor
Elsevier, 2024.
Nyckelord [en]
Adjuvant therapy, Biochemical recurrence, Bone protection, Genetics and genomics, Hormonal treatment, Next-generation imaging, Positron emission tomography, Prostate cancer, Prostate-specific membrane antigen, Salvage therapy
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Klinisk medicin
Identifikatorer
URN: urn:nbn:se:umu:diva-231024DOI: 10.1016/j.eururo.2024.09.017PubMedID: 39394013Scopus ID: 2-s2.0-85206186686OAI: oai:DiVA.org:umu-231024DiVA, id: diva2:1910177
Tillgänglig från: 2024-11-04 Skapad: 2024-11-04 Senast uppdaterad: 2025-02-18

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Thellenberg-Karlsson, Camilla

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