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Introduction: A high chlamydia infection rate of 1800 per 100.000 people and 2500 per 100.000 people has been reported for women in the reproductive age 15-19, and 20-24 years respectively. Untreated genital chlamydia infection is associated with deteriorated sexual and reproductive health. Despite the health problems posed by this infection, it is still largely undiagnosed and untreated among young girls in Cameroon, mainly because they experience challenges in the accessibility and availability of sexual and reproductive health services. This study’s aim was to evaluate the cost-effectiveness of implementing a youth sexual and reproductive health intervention(YSRHI) for chlamydia management compared to standard of care among young women in the age of 15-24 years in Cameroon.

Method: This study is a health economic modelling study that used a Markov model design to evaluate a hypothetical YSRHI program focused on chlamydia prevention, treatment, and follow-up. Deterministic sensitivity analysis was performed by alternating key parameters in the model.

Results: The cost of implementing YSRHI was $450 per QALY gained for the age group 15-19years, and $1,955 per QALY gained for the age group 20-24 years. All parameters in the sensitivity analysis were still cost-effective for the younger age group, however, a parameter like increasing the intervention costs was not cost-effective for the older age group.

Conclusion: A YSRHI is cost-effective based on the WHO-CHOICE recommendations of 3x GDP/capita per QALY gained. However, it is worth noting that these results are based on assumptions regarding the natural history of chlamydia.