GBA1 T369M and Parkinson's disease - Further evidence of a lack of association in the Swedish population Show others and affiliations
2025 (English) In: Parkinsonism & Related Disorders, ISSN 1353-8020, E-ISSN 1873-5126, Vol. 130, article id 107191Article in journal (Refereed) Published
Abstract [en]
Variants in GBA1 are important genetic risk factors in Parkinson's disease (PD). GBA1 T369M has been linked to an ∼80 % increased PD risk but the reports are conflicting and the relevance of GBA1 variants in different populations varies. A lack of association between T369M and PD in the Swedish population was recently reported but needs further validation. We therefore investigated T369M in 1,808 PD patients and 2,183 controls and our results support that T369M is not a risk factor for PD in the Swedish population.
Place, publisher, year, edition, pages Elsevier, 2025. Vol. 130, article id 107191
National Category
Neurology
Identifiers URN: urn:nbn:se:umu:diva-231641 DOI: 10.1016/j.parkreldis.2024.107191 Scopus ID: 2-s2.0-85208201476 OAI: oai:DiVA.org:umu-231641 DiVA, id: diva2:1914282
Funder Swedish Research Council, 2022-00775 Knut and Alice Wallenberg Foundation, 2022-0231 The Swedish Brain Foundation, FO2021-0293 Parkinsonfonden, 1412/22 Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse Region Skåne Hans-Gabriel och Alice Trolle-Wachtmeisters stiftelse för medicinsk forskning 2024-11-192024-11-192024-11-19 Bibliographically approved