People with disability make up the largest minority group worldwide. Despite advocacy work and political advances in disability rights, such as the UN Convention on the Rights of Persons with Disabilities, these people are still marginalised in society, and disability is often considered solely a medical condition associated with personal tragedy and exclusion. The European Research Council funded the DISLIFE project to research disability in Sweden from the 1800s until present time from life course perspectives. This chapter gives an overview of the project and highlights some key findings on how societal circumstances have shaped the opportunities and lives of people with disability across time. We explain the project's use of the life course concept and reflect critically upon it from ableist perspectives. In all, the project findings suggest there has been little improvement over time of the life opportunities of people with disability.