Umeå universitets logga

umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Spatial transcriptomics, proteomics, and epigenomics as tools in tissue engineering and regenerative medicine
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk och translationell biologi. (Chondrogenic and osteogenic differentiation)ORCID-id: 0000-0002-6181-9904
Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.ORCID-id: 0000-0002-1710-7715
2024 (Engelska)Ingår i: Bioengineering, E-ISSN 2306-5354, Vol. 11, nr 12, artikel-id 1235Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Spatial transcriptomics, proteomics, and epigenomics are innovative technologies which offer an unparalleled resolution and wealth of data in understanding and the interpretation of cellular functions and interactions. These techniques allow researchers to investigate gene and protein expressions at an individual cell level, revealing cellular heterogeneity within, for instance, bioengineered tissues and classifying novel and rare cell populations that could be essential for the function of the tissues and in disease processes. It is possible to analyze thousands of cells simultaneously, which gives thorough insights into the transcriptomic view of complex tissues. Spatial transcriptomics combines gene expressions with spatial information, conserving tissue architecture and making the mapping of gene activity across different tissue regions possible. Despite recent advancements in these technologies, they face certain limitations. Single-cell transcriptomics can suffer from technical noise and dropout events, leading to incomplete data. Its applicability has been limited by the complexity of data integration and interpretation, although better resolution and tools for the interpretation of data are developing fast. Spatial proteomics and spatial epigenomics provide data on the distribution of proteins and the gene regulatory aspects in tissues, respectively. The disadvantages of these approaches include rather costly and time-consuming analyses. Nevertheless, combining these techniques promises a more comprehensive understanding of cell function and tissue organization, which can be predicted to be useful in achieving better knowledge of cell guidance in tissue-engineered constructs and a higher quality of tissue technology products.

Ort, förlag, år, upplaga, sidor
MDPI , 2024. Vol. 11, nr 12, artikel-id 1235
Nyckelord [en]
bioengineering, regenerative medicine, single-cell RNA sequencing, spatial multiomics
Nationell ämneskategori
Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)
Forskningsämne
cellforskning; medicinsk cellbiologi; molekylär bioteknik (inst f molekylärbiologi)
Identifikatorer
URN: urn:nbn:se:umu:diva-233800DOI: 10.3390/bioengineering11121235ISI: 001387299200001PubMedID: 39768053Scopus ID: 2-s2.0-85213285449OAI: oai:DiVA.org:umu-233800DiVA, id: diva2:1925353
Tillgänglig från: 2025-01-08 Skapad: 2025-01-08 Senast uppdaterad: 2025-01-08Bibliografiskt granskad

Open Access i DiVA

fulltext(193 kB)12 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 193 kBChecksumma SHA-512
b46a11f3db4a3baa46495ffb437f3c1d4e86d351f555fd3fe9a4c55537f626ad8a472e2a58541975c8709576fe5432a33f5c37d071c04056a66f8e11591d4919
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMedScopus

Person

Lammi, MikkoQu, Chengjuan

Sök vidare i DiVA

Av författaren/redaktören
Lammi, MikkoQu, Chengjuan
Av organisationen
Institutionen för medicinsk och translationell biologiInstitutionen för odontologi
I samma tidskrift
Bioengineering
Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 12 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 147 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf