Evidence for a mediator cycle at the initiation of transcription Show others and affiliations
1997 (English) In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 94, no 12, p. 6075-6078Article in journal (Refereed) Published
Abstract [en]
Free and elongating (DNA-bound) forms of RNA polymerase II were separated from yeast. Most cellular polymerase II was found in the elongating fraction, which contained all enzyme phosphorylated on the C-terminal domain and none of the 15-subunit mediator of transcriptional regulation. These and other findings suggest that mediator enters and leaves initiation complexes during every round of transcription, in a process that may be coupled to C-terminal domain phosphorylation.
Place, publisher, year, edition, pages Proceedings of the National Academy of Sciences (PNAS), 1997. Vol. 94, no 12, p. 6075-6078
National Category
Molecular Biology
Identifiers URN: urn:nbn:se:umu:diva-236221 DOI: 10.1073/pnas.94.12.6075 ISI: A1997XD84400020 PubMedID: 9177171 Scopus ID: 2-s2.0-0030947346 OAI: oai:DiVA.org:umu-236221 DiVA, id: diva2:1943021
2025-03-072025-03-072025-03-10 Bibliographically approved