Deep learning has been used extensively for medical image analysis applications, assuming the training and test data adhere to the same probability distributions. However, a common challenge arises when dealing with medical images generated by different systems or even the same system with varying parameter settings. Such images often contain diverse textures and noise patterns, violating the assumption. Consequently, models trained on data from one machine or setting usually struggle to perform effectively on data from another. To address this issue in ultrasound images, we proposed a Generative Adversarial Network (GAN) based model in this paper. We formulated image harmonization and denoising tasks as an image-to-image translation task, wherein we adapt the texture pattern and reduced noise in Carotid ultrasound images while keeping the image content (the anatomy) unchanged. The performance was evaluated using feature distribution and pixel-space similarity metrics. In addition, blood-to-tissue contrast and influence on computed risk markers (Grey scale median, GSM) were evaluated. The results showed that domain adaptation was achieved in both tasks (histogram correlation 0.920 (0.043) and 0.844 (0.062)), as compared to no adaptation (0.890 (0.077) and 0.707 (0.098)), and that the anatomy of the images was retained (structure similarity index measure e.g. the arterial wall 0.71 (0.09) and 0.80 (0.08)). In addition, the image noise level (contrast) did not change in the image harmonization task (-34.1 (3.8) vs -35.2 (4.1) dB) but was improved in the noise reduction task (-23.5 (3.2) vs -46.7 (18.1) dB). To validate the performance of the proposed model, we compare its results with CycleGAN, the current state-of-the-art model. Our model outperformed CycleGAN in both tasks. Finally, the risk marker GSM was significantly changed in the noise reduction but not in the image harmonization task. We conclude that domain translation models are powerful tools for improving ultrasound image while retaining the underlying anatomy, but downstream calculations of risk markers may be affected.