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Children with congenital and acquired heart disease have an increased risk of thromboembolic events. There is a paucity of evidence on the optimal approach to thromboprophylaxis for this population, and the introduction of direct oral anticoagulants in recent years has led to significant variation in clinical practice. The aim of the study was to describe current practice in thromboprophylaxis prescribing amongst European Paediatric Cardiology units managing paediatric and congenital heart disease. A structured and approved online survey (SurveyMonkey.com) was developed for distribution to AEPC affiliated paediatric cardiology centres in Europe. Responses were received from 30 participants working in 27 Paediatric Cardiology centres across Europe. There is significant variation between participants in the approach to thromboprophylaxis in different patient cohorts, including functional single ventricle patients, post-cardiac catheterisation intervention/electrophysiology study, post-prosthetic valve insertion, cardiomyopathy/heart failure, and infective endocarditis. Differences were seen in the indications for thromboprophylaxis, as well as the agents used and the duration of treatment. Conclusion: There is significant variation in practice amongst participants in Europe. Further studies are required in order to develop evidence-based guidelines for clinical practice. (Table presented.)