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Analysis of the mRNA modification machinery alterations in breast cancer through the SCAN-B cohort
Department of Cellular Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy.
Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).ORCID iD: 0000-0002-8047-9298
Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Department of Cellular Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy.
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2025 (English)In: NAR Cancer, E-ISSN 2632-8674, Vol. 7, no 3, article id zcaf027Article in journal (Refereed) Published
Abstract [en]

Epitranscriptomic modifications regulate gene expression and have been implicated in cancer, including breast cancer. Using the SCAN-B cohort, we analyzed 49 messenger RNA modification regulators (mRMPs) across breast cancer subtypes. In the basal subtype, we found significant overexpression of m6A readers (IGF2BP1-3), m5C regulators (NSUN5, ALYREF, YBX1, YBX2), pseudouridine [PUS1, MARS (or MetRS), RPUSD2], and RNA editing enzymes [APOBEC3A (A3A), A3G, ADAR1], all linked to poor survival. Conversely, the m6A writer METTL14 was downregulated. Our findings highlight key mRMPs as potential biomarkers and therapeutic targets, underscoring the role of RNA modifications in breast cancer progression.
Place, publisher, year, edition, pages
Oxford University Press, 2025. Vol. 7, no 3, article id zcaf027
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Cancer and Oncology
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URN: urn:nbn:se:umu:diva-244573DOI: 10.1093/narcan/zcaf027ISI: 001563419700001PubMedID: 40918643Scopus ID: 2-s2.0-105015418310OAI: oai:DiVA.org:umu-244573DiVA, id: diva2:2003745
Funder
Knut and Alice Wallenberg FoundationUmeå UniversityRegion VästerbottenSwedish Research Council, 2017-01636Swedish Research Council, 2022-01322The Kempe Foundations, JCK-2150Swedish Cancer Society, 190337 PjSwedish Cancer Society, 22 2455 PjAvailable from: 2025-10-04 Created: 2025-10-04 Last updated: 2025-10-04Bibliographically approved

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Esteva-Socias, MargalidaKumari, KanchanAguilo, Francesca

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Esteva-Socias, MargalidaKumari, KanchanAguilo, Francesca
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